Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Deep Brain Stimulation for Essential Tremor and Other Tremor Syndromes: A Narrative Review of Current Targets and Clinical Outcomes

Version 1 : Received: 28 October 2020 / Approved: 30 October 2020 / Online: 30 October 2020 (10:21:14 CET)

A peer-reviewed article of this Preprint also exists.

Iorio-Morin, C.; Fomenko, A.; Kalia, S.K. Deep-Brain Stimulation for Essential Tremor and Other Tremor Syndromes: A Narrative Review of Current Targets and Clinical Outcomes. Brain Sci. 2020, 10, 925. Iorio-Morin, C.; Fomenko, A.; Kalia, S.K. Deep-Brain Stimulation for Essential Tremor and Other Tremor Syndromes: A Narrative Review of Current Targets and Clinical Outcomes. Brain Sci. 2020, 10, 925.

Abstract

Tremor is a prevalent symptom associated with multiple conditions, including Essential Tremor (ET), Parkinson’s disease (PD), multiple sclerosis (MS), stroke, and trauma. The surgical management of tremor evolved from stereotactic lesions to deep-brain stimulation (DBS), which allowed safe and reversible interference with specific neural networks. This paper reviews the current literature on DBS for tremor, starting with a detailed discussion of current tremor targets (Vim, Raprl, caudal Zi, Vo and STN) and continuing with a discussion of results obtained when performing DBS in the various aforementioned tremor syndromes. Future directions for DBS research are then briefly discussed.

Keywords

DBS; Tremor; Essential Tremor; Parkinson’s disease; Multiple Sclerosis; Stroke; Trauma; Holmes tremor

Subject

Medicine and Pharmacology, Immunology and Allergy

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