Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

In-Silico Study of the Immune Systems Associated Genes in Case of Type-2 Diabetes with Insulin Action and Resistance and in Obesity

Version 1 : Received: 14 October 2020 / Approved: 15 October 2020 / Online: 15 October 2020 (09:47:35 CEST)

How to cite: Eldakhakhny, B.M.; Sadoun, H.A.; Choudhry, H.; Mobashir, M. In-Silico Study of the Immune Systems Associated Genes in Case of Type-2 Diabetes with Insulin Action and Resistance and in Obesity. Preprints 2020, 2020100316 (doi: 10.20944/preprints202010.0316.v1). Eldakhakhny, B.M.; Sadoun, H.A.; Choudhry, H.; Mobashir, M. In-Silico Study of the Immune Systems Associated Genes in Case of Type-2 Diabetes with Insulin Action and Resistance and in Obesity. Preprints 2020, 2020100316 (doi: 10.20944/preprints202010.0316.v1).

Abstract

Obesity, type 2 diabetes, and different forms of cancers are among the leading human diseases and highly complex in terms of diagnostic and therapeutic approaches. Diabetes and cancer are among the most frequent and complex diseases and based on epidemiological evidence and study it can be concluded that the patients suffering from diabetes are considered to be significantly at higher risk for a number of cancer types. Both these diseases are among the highly complex and heterogeneous in nature. There are a number of evidences which support the hypothesis that these diseases interlinked and obesity may aggravate the risk(s) of both these diseases type 2 diabetes and different types of cancers. Multi-level unwanted alterations such as (epi-)genetic alterations, changes at the transcriptional level, and altered signaling pathways (receptor, cytoplasmic, and nuclear level) are the major source which promotes a number of complex diseases and such heterogeneous level of complexities are considered as the major barrier in the development of therapeutic. With so many known challenges, it is critical to understand the relationships and the common shared causes between type 2 diabetes and cancer which is difficult to unravel and understand. Furthermore, the real complexity arises during diagnosis from contended corroborations that specific drug(s) (individually or in combination) during diagnosis process of type 2 diabetes may increase or decrease the cancer risk or affect cancer prognosis. In this review article, we have presented the recent and most updated evidences from the studies where the origin, biological background, correlation between them have been presented or proved. Furthermore, we have summarized the methodological challenges and tasks that are frequently encountered. we have also outlined the physiological links between type 2 diabetes and cancers. Finally, we have presented and summarized the outline of the hallmarks for both these diseases diabetes and cancer.

Subject Areas

Type 2 diabetes; cancer; shared pathways; shared genes and proteins; relationship between cancer and type 2 diabetes

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