Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Investigating the Potential of 8-Amidoquinoline Derivatives as a Fluorescent Probe for Zinc Detection: A Systematic Literature Review

Version 1 : Received: 5 October 2020 / Approved: 6 October 2020 / Online: 6 October 2020 (14:55:13 CEST)

How to cite: Hassan, N.I.; Mohamad, N.S.; Zakaria, N.H.; Daud, N.; Tan, L.L.; Ta, G.C.; Heng, L.Y. Investigating the Potential of 8-Amidoquinoline Derivatives as a Fluorescent Probe for Zinc Detection: A Systematic Literature Review. Preprints 2020, 2020100134 (doi: 10.20944/preprints202010.0134.v1). Hassan, N.I.; Mohamad, N.S.; Zakaria, N.H.; Daud, N.; Tan, L.L.; Ta, G.C.; Heng, L.Y. Investigating the Potential of 8-Amidoquinoline Derivatives as a Fluorescent Probe for Zinc Detection: A Systematic Literature Review. Preprints 2020, 2020100134 (doi: 10.20944/preprints202010.0134.v1).

Abstract

Abundant of preparatory works have recognized that fluorescent sensors based on 8-aminoquinoline are popular tools to detect Zn2+ ions in environmental and biological applications. Along with these studies, researchers started to introduce a variety of carboxamido group into an 8-aminoquinoline molecule in forming 8-amidoquinoline derivatives. Therefore, this systematic review aims to introduce a general overview of the fluorophore 8-aminoquinoline as Zn2+ receptors and to provide comparisons of collected studies that related to 8-amidoquinoline derivatives as fluorophore probe of the sensor. According to PRISMA systematic searches strategy, 13 articles were analyzed for trends, research designs, results and discussion, subject samples, and remarks or conclusions. We found cross-sectional studies with four aspects in zinc sensing that have been targeted; binding studies via titration, detection's limit, interferences studies, and validation of the study. Hence, this paper also included assessments of those criteria and the trends of development of 8-amidoquinoline derivatives based-zinc fluorescent chemosensor. It also showed that most of the researches conducted in China. In conclusion, this study identified various research designs of fluorescent chemosensors based on 8-amidoquinoline prolong with the effectiveness and potential as a recognition probe to assist the detection of zinc. Hence, elucidation of those derivatives essential to be explored because more studies are needed to improve the sensing criteria of the zinc sensor

Subject Areas

zinc sensor; 8-amidoquinoline; fluorescent probe; chemosensor; systematic review

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