Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A

Sachiko Komatsu; Yusuke Sasano; Kyoko Sugiyama; Kazuhiro Watanabe; Masayuki Kumano; Kentaro Yoshida; Tetsuya Ono; Yoshiharu Iwabuchi; Tsutomu Fujimura; Katsuhiko Sato; Yoshitomo Kashiwagi

doi:10.20944/preprints202010.0105.v1

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preprints.org > chemistry and materials science > analytical chemistry > doi: 10.20944/preprints202010.0105.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A

^* ,

Version 1 : Received: 5 October 2020 / Approved: 5 October 2020 / Online: 5 October 2020 (20:19:21 CEST)

A peer-reviewed article of this Preprint also exists.

Komatsu, S.; Sasano, Y.; Sugiyama, K.; Watanabe, K.; Kumano, M.; Yoshida, K.; Ono, T.; Iwabuchi, Y.; Fujimura, T.; Sato, K.; et al. Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A. International Journal of Electrochemical Science 2021, 16, 21027, doi:10.20964/2021.02.30. Komatsu, S.; Sasano, Y.; Sugiyama, K.; Watanabe, K.; Kumano, M.; Yoshida, K.; Ono, T.; Iwabuchi, Y.; Fujimura, T.; Sato, K.; et al. Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A. International Journal of Electrochemical Science 2021, 16, 21027, doi:10.20964/2021.02.30.

Abstract

Nitroxyl radical catalysts oxidize alcohols under an applied electric potential. It is possible to quantify the alcohol concentration from the resulting oxidation current. In this work, we evaluated the catalytic activity of nitroxyl radicals (or their corresponding hydroxylamines), including 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) as representative nitroxyl radicals, acetoamido-TEMPO, which shows higher oxidation potential than TEMPO owing to the acetoamido group, AZADO, Nor-AZADO, and NNO as less-hindered bicyclic nitroxyl radicals, and NHPI as an N,N-diacyl-type hydroxylamine, in acetonitrile solution. TEMPO, AZADO and NNO were also evaluated for their ability to oxidize alcohols in organic solvents, and their reactivity was compared with the electrochemical response. The most active NNO was used for electrochemical detection of cyclosporin A, a drug with a hydroxyl group.

Keywords

nitroxyl radical; TEMPO; cyclosporine A; sensor

Subject

Chemistry and Materials Science, Analytical Chemistry

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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