Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A

Version 1 : Received: 5 October 2020 / Approved: 5 October 2020 / Online: 5 October 2020 (20:19:21 CEST)

How to cite: Komatsu, S.; Sasano, Y.; Sugiyama, K.; Watanabe, K.; Kumano, M.; Yoshida, K.; Ono, T.; Iwabuchi, Y.; Fujimura, T.; Sato, K.; Kashiwagi, Y. Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A. Preprints 2020, 2020100105 (doi: 10.20944/preprints202010.0105.v1). Komatsu, S.; Sasano, Y.; Sugiyama, K.; Watanabe, K.; Kumano, M.; Yoshida, K.; Ono, T.; Iwabuchi, Y.; Fujimura, T.; Sato, K.; Kashiwagi, Y. Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A. Preprints 2020, 2020100105 (doi: 10.20944/preprints202010.0105.v1).

Abstract

Nitroxyl radical catalysts oxidize alcohols under an applied electric potential. It is possible to quantify the alcohol concentration from the resulting oxidation current. In this work, we evaluated the catalytic activity of nitroxyl radicals (or their corresponding hydroxylamines), including 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) as representative nitroxyl radicals, acetoamido-TEMPO, which shows higher oxidation potential than TEMPO owing to the acetoamido group, AZADO, Nor-AZADO, and NNO as less-hindered bicyclic nitroxyl radicals, and NHPI as an N,N-diacyl-type hydroxylamine, in acetonitrile solution. TEMPO, AZADO and NNO were also evaluated for their ability to oxidize alcohols in organic solvents, and their reactivity was compared with the electrochemical response. The most active NNO was used for electrochemical detection of cyclosporin A, a drug with a hydroxyl group.

Subject Areas

nitroxyl radical; TEMPO; cyclosporine A; sensor

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.