Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Non-Canonical Functions of the γTubulin Meshwork in the Regulation of the Nuclear Architecture

Version 1 : Received: 1 October 2020 / Approved: 5 October 2020 / Online: 5 October 2020 (09:16:02 CEST)

A peer-reviewed article of this Preprint also exists.

Corvaisier, M.; Alvarado-Kristensson, M. Non-Canonical Functions of the Gamma-Tubulin Meshwork in the Regulation of the Nuclear Architecture. Cancers 2020, 12, 3102. Corvaisier, M.; Alvarado-Kristensson, M. Non-Canonical Functions of the Gamma-Tubulin Meshwork in the Regulation of the Nuclear Architecture. Cancers 2020, 12, 3102.

Journal reference: Cancers 2020, 12, 3102
DOI: 10.3390/cancers12113102

Abstract

The nuclear architecture describes the organization of the various compartments in the nucleus of eukaryotic cells, where a plethora of processes such as nucleocytoplasmic transport, gene expression, and assembly of ribosomal subunits occur in a dynamic manner. During the different phases of the cell cycle, in post-mitotic cells and after oncogenic transformation, rearrangements of the nuclear architecture take place, and, among other things, these alterations result in reorganization of the chromatin and changes in gene expression. A member of the tubulin family, tubulin, was first identified as part of a multiprotein complex that allows nucleation of microtubules. However, more than a decade ago, γ tubulin was also characterized as a nuclear protein that modulates several crucial processes that affect the architecture of the nucleus. This review presents the latest knowledge regarding changes that arise in the nuclear architecture of healthy cells and under pathological conditions and, more specifically, considers the particular involvement of tubulin in the modulation of the biology of the nuclear compartment.

Subject Areas

γtubulin; nuclear architecture; cytoskeleton; nuclearskeleton; cancer; differentiation

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