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How to Understand Cells Well Enough to Predict Evolution: Polarity Establishment in Budding Yeast as a Case Study
Version 1
: Received: 30 September 2020 / Approved: 1 October 2020 / Online: 1 October 2020 (12:19:35 CEST)
A peer-reviewed article of this Preprint also exists.
Daalman, W. .-G.; Sweep, E.; Laan, L. The Path towards Predicting Evolution as Illustrated in Yeast Cell Polarity. Cells 2020, 9, 2534. Daalman, W. .-G.; Sweep, E.; Laan, L. The Path towards Predicting Evolution as Illustrated in Yeast Cell Polarity. Cells 2020, 9, 2534.
Abstract
A bottom-up route towards predicting evolution relies on deep understanding of the complex network proteins form inside cells. In a rapidly expanding panorama of experimental possibilities, the most difficult question is how to conceptually approach the disentangling of such complex networks. These can exhibit varying degrees of hierarchy and modularity, which obfuscate certain protein functions that may prove pivotal for adaptation. Using the well-established polarity network in budding yeast as a case study, we first organize current literature to highlight protein entrenchments inside polarity. Following three examples, we see how alternating between experimental novelties and subsequent emerging design strategies can construct a layered understanding, potent enough to reveal evolutionary targets. We show that if you want to understand a cell’s evolutionary capacity, such as possible future evolutionary paths, seemingly unimportant proteins need to be mapped and studied. Finally, we generalize this research structure to be applicable to other systems of interest.
Keywords
network evolution; Saccharomyces cerevisiae; polarity; modularity; neutrality; symmetry breaking; Cdc42; pattern formation
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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