Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Structure-Function Relationships of Nuclear Lamins

Version 1 : Received: 24 September 2020 / Approved: 25 September 2020 / Online: 25 September 2020 (11:03:59 CEST)

How to cite: Patil, S.; Sengupta, K. Structure-Function Relationships of Nuclear Lamins. Preprints 2020, 2020090604 (doi: 10.20944/preprints202009.0604.v1). Patil, S.; Sengupta, K. Structure-Function Relationships of Nuclear Lamins. Preprints 2020, 2020090604 (doi: 10.20944/preprints202009.0604.v1).

Abstract

Nuclear lamins are type V intermediate filament proteins that form a filamentous meshwork beneath the inner nuclear membrane. Additionally, a sub-population of A-type and B-type lamins is localized in the nuclear interior. The nuclear lamina protects the nucleus from mechanical stress and mediates nucleo-cytoskeletal coupling. Lamins form a scaffold that partially tethers chromatin at the nuclear envelope. The nuclear lamina also stabilizes protein-protein interactions involved in gene regulation and DNA repair. The lamin-based protein sub-complexes are implicated in both nuclear and cytoskeletal organization, the mechanical stability of the nucleus, genome organization, transcriptional regulation, genome stability, and cellular differentiation. Here we review recent research in the field of nuclear lamins and their role in modulating various nuclear processes and their impact on cell function.

Subject Areas

Nucleus; Nuclear envelope; Lamins; Genome organization; Chromatin; Gene expression

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