Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Post-Operative Infectious Complications in Pancreatic Surgery – A Systemic Review and Updated Meta-analysis

Version 1 : Received: 22 September 2020 / Approved: 23 September 2020 / Online: 23 September 2020 (08:07:40 CEST)

How to cite: Vasavada, B.; patel, H. Post-Operative Infectious Complications in Pancreatic Surgery – A Systemic Review and Updated Meta-analysis. Preprints 2020, 2020090545 (doi: 10.20944/preprints202009.0545.v1). Vasavada, B.; patel, H. Post-Operative Infectious Complications in Pancreatic Surgery – A Systemic Review and Updated Meta-analysis. Preprints 2020, 2020090545 (doi: 10.20944/preprints202009.0545.v1).

Abstract

Aim of study:Aim of this meta-analysis is to evaluate post-operative procalcitonin as a marker to predict post- operative infectious complications after pancreatic surgeries.Material and Methods:Systemic literature search was performed using MEDLINE, EMBASE and to identify studies evaluating the diagnostic accuracy of Procalcitonin (PCT) as a predictor for detecting infectious complications on postoperative days (POD) 3 and 5 following pancreatic surgery. A meta-analysis was performed using random effect model and pooled predictive parameters for POD 3 and 5 were derived. Geometric means were calculated for PCT cut offs. Results:6 studies included day 3 PCT analysis, 2 studies included both day 3 and day 5 analysis. Total data of 471 patients were derived. 161 patients developed infectious complications. Pooled sensitivity, specificity, pooled area under curve, diagnostic odds ratio (DOR), positive and negative like hood ratio of day 3 PCT were 74%,79%,0.8453, 11.03,3.17 and 0.31 respectively. Pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive and negative like hood ratio of day 5 PCT were 83%,70%,12.91,2.91 and 0.25 respectively. Geometric means for PCT cut off for day 3 and 5 were 0.80 and 0.43. Conclusion:Postoperative procalcitonin particularly day 3 procalcitonin levels predict post-operative infectious complications following pancreatic surgeries.

Subject Areas

Meta-analysis; Procalcitonin; pancreatic surgery; pancreaticoduodenectomy; Infectious complications

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