Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Role of Phosphoinositides in Cellular Signaling, Functions and Diseases

Version 1 : Received: 21 September 2020 / Approved: 22 September 2020 / Online: 22 September 2020 (09:04:28 CEST)

How to cite: Mandal, K. Role of Phosphoinositides in Cellular Signaling, Functions and Diseases. Preprints 2020, 2020090513 (doi: 10.20944/preprints202009.0513.v1). Mandal, K. Role of Phosphoinositides in Cellular Signaling, Functions and Diseases. Preprints 2020, 2020090513 (doi: 10.20944/preprints202009.0513.v1).

Abstract

In this review we summarize the recent development in understanding the role of PIP2 in cellular function and signaling. We first discuss the effect of PIP2 on actin binding proteins addressing the mechanism of the actin cytoskeletal dynamics such as polymerization or depolymerization of the filamentous network or the coupling to membrane to generate forces. Next, we outline the role of PIP2 in membrane dynamics. We summarized how the membrane organization depends upon PIP2 in the presence of ions or transmembrane proteins that are sensitive to membrane curvature. We discuss how clathrin coated pits interact with adaptor proteins during the endocytosis process, which is facilitated by PIP2. Finally, we discuss the role of PIP2 in cell signaling and diseases.

Subject Areas

PIP2; membrane dynamics; disease; actin dynamics; phosphoinositides; signaling

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