Working PaperReviewVersion 1This version is not peer-reviewed
The Alterations of Cellular Signaling Pathways in the Host Cell upon the High Pathogenic Coronaviruses Infection, SARS-CoV and MERS-CoV. What Could Be Expected from the SARS-CoV-2?
Version 1
: Received: 17 September 2020 / Approved: 21 September 2020 / Online: 21 September 2020 (04:17:24 CEST)
How to cite:
Hemmat, N.; Asadzadeh, Z.; Karim-ahangar, N.; Alemohammad, H.; Najafzadeh, B.; Derakhshani, A.; Baghbanzadeh, A.; Bannazadeh Baghi, H.; Javadrashid, D.; Najafi, S.; Ar Gouilh, M.; Baradaran, B. The Alterations of Cellular Signaling Pathways in the Host Cell upon the High Pathogenic Coronaviruses Infection, SARS-CoV and MERS-CoV. What Could Be Expected from the SARS-CoV-2?. Preprints2020, 2020090489
Hemmat, N.; Asadzadeh, Z.; Karim-ahangar, N.; Alemohammad, H.; Najafzadeh, B.; Derakhshani, A.; Baghbanzadeh, A.; Bannazadeh Baghi, H.; Javadrashid, D.; Najafi, S.; Ar Gouilh, M.; Baradaran, B. The Alterations of Cellular Signaling Pathways in the Host Cell upon the High Pathogenic Coronaviruses Infection, SARS-CoV and MERS-CoV. What Could Be Expected from the SARS-CoV-2?. Preprints 2020, 2020090489
Cite as:
Hemmat, N.; Asadzadeh, Z.; Karim-ahangar, N.; Alemohammad, H.; Najafzadeh, B.; Derakhshani, A.; Baghbanzadeh, A.; Bannazadeh Baghi, H.; Javadrashid, D.; Najafi, S.; Ar Gouilh, M.; Baradaran, B. The Alterations of Cellular Signaling Pathways in the Host Cell upon the High Pathogenic Coronaviruses Infection, SARS-CoV and MERS-CoV. What Could Be Expected from the SARS-CoV-2?. Preprints2020, 2020090489
Hemmat, N.; Asadzadeh, Z.; Karim-ahangar, N.; Alemohammad, H.; Najafzadeh, B.; Derakhshani, A.; Baghbanzadeh, A.; Bannazadeh Baghi, H.; Javadrashid, D.; Najafi, S.; Ar Gouilh, M.; Baradaran, B. The Alterations of Cellular Signaling Pathways in the Host Cell upon the High Pathogenic Coronaviruses Infection, SARS-CoV and MERS-CoV. What Could Be Expected from the SARS-CoV-2?. Preprints 2020, 2020090489
Abstract
Emerging viruses description have grown at an unprecedented rate since the beginning of the 21st century. The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its related illness, Coronavirus Disease 2019 (COVID-19) has been reported as the third highly pathogenic coronavirus introducing itself into human population in the current era after the SARS-CoV and Middle East Respiratory Syndrome (MERS-CoV). Molecular and cellular studies considering the pathogenesis of this novel coronavirus are still in the early stages of research, however, regarding the similarity of SARS-CoV-2 and other coronaviruses, it could be hypothesized that the NF-κB, Cytokine regulation, ERK, and TNF-α signaling pathways are the more likely causes of inflammation upon onset of COVID-19. There are several drugs prescribed and used to alleviate the activity of these inflammatory cellular signaling pathways which might be beneficial for developing novel therapeutic modalities against COVID-19. In this review, we briefly summarized the alteration of cellular signaling pathways affected by coronavirus infection, particularly SARS-CoV and MERS-CoV and tabulated the current therapeutic agents approved for previous human diseases.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Nima Hemmat
*
,
Afshin Derakhshani
,
Darya Javadrashid
,
Behzad Baradaran
*