Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility

Version 1 : Received: 16 September 2020 / Approved: 18 September 2020 / Online: 18 September 2020 (07:09:31 CEST)

A peer-reviewed article of this Preprint also exists.

Esfandyari, S.; Chugh, R.M.; Park, H.-S.; Hobeika, E.; Ulin, M.; Al-Hendy, A. Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility. Cells 2020, 9, 2253. Esfandyari, S.; Chugh, R.M.; Park, H.-S.; Hobeika, E.; Ulin, M.; Al-Hendy, A. Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility. Cells 2020, 9, 2253.

Journal reference: Cells 2020, 9, 2253
DOI: 10.3390/cells9102253

Abstract

Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency and to improve reproductive health for a significant number of women worldwide.

Subject Areas

Infertility; mesenchymal stem cells (MSCs); reproductive system; Stem-cell therapy

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