Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy

Version 1 : Received: 13 September 2020 / Approved: 13 September 2020 / Online: 13 September 2020 (16:16:59 CEST)
Version 2 : Received: 18 September 2020 / Approved: 19 September 2020 / Online: 19 September 2020 (04:49:18 CEST)

How to cite: Gomes, I.C.; Karmirian, K.; Oliveira, J.; Pedrosa, C.; Rosman, F.C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy. Preprints 2020, 2020090297 (doi: 10.20944/preprints202009.0297.v1). Gomes, I.C.; Karmirian, K.; Oliveira, J.; Pedrosa, C.; Rosman, F.C.; Chimelli, L.; Rehen, S. SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy. Preprints 2020, 2020090297 (doi: 10.20944/preprints202009.0297.v1).

Abstract

Coronavirus disease 2019 (COVID-19) was initially characterized as a respiratory illness. Neurological manifestations were reported mostly in severely affected patients. Routes for brain infection and the presence of virus particles in situ have not been well described, raising controversy about how the virus causes neurological symptoms. Here, we report the autopsy findings of a 1-year old infant with COVID-19. In addition to pneumonitis, meningitis and multiple organ damage related to thrombosis, a previous encephalopathy may have contributed to additional cerebral damage. SARS-CoV-2 infected the choroid plexus, ventricles, and cerebral cortex. This is the first evidence of SARS-CoV-2 detection in an infant post-mortem brain.

Subject Areas

SARS-CoV-2; COVID-19; CNS; infant; Choroid plexus

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