Preprint
Article

Evaluation of Column Test Methods to Study Inactivation of Chemically Bonded Silica Gels

This version is not peer-reviewed.

Submitted:

01 September 2020

Posted:

03 September 2020

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Abstract
The silanol activity and trace metal detection methods for chemically bonded silica gels were evaluated in silico. Test compounds with large molecular sizes may demonstrate negative results because of the possibility of indirect hydrogen bonding via short alkyl groups or siloxane of the silica gels. This hypothesis was based on the observation of weak hydrogen bonding energy values similar to those observed in the study of the alkyl group effect on the hydrogen bonding of alkanols. Consequently, smaller molecules may be a better choice for the analysis of bonded-phase quality.
Keywords: 
inactivation column test; silanol; trace metals; in silico; bonded-phase silica
Subject: 
Chemistry and Materials Science  -   Analytical Chemistry
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.

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