Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Characterization of Andean Blueberry in Bioactive Compounds, Evaluation of Biological Properties and in vitro Bioaccessibility

Version 1 : Received: 1 September 2020 / Approved: 3 September 2020 / Online: 3 September 2020 (04:43:08 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: Foods 2020, 9, 1483
DOI: 10.3390/foods9101483


Andean blueberries are wild berries grown and consumed in Ecuador which contain high values of bioactive compounds, mainly anthocyanins, with powerful antioxidant activity. The aim of this study was to evaluate the profile and contents of (poly)phenols and carotenoids in Andean blueberry by HPLC-DAD-MSn and determine a wide range of its biological activities. The antioxidant capacity of this fruit was evaluated in vitro by three different methods and in vivo using the zebrafish animal model, also the toxicity effect was determined by the zebrafish embryogenesis test. Besides, the antimicrobial activity and the capacity of Andean blueberry to produce hemagglutination in blood cells were evaluated. Finally, the bioaccessibility of (poly)phenols and related antioxidant capacity were determined in the different phases of an in vitro digestion. The global results indicated no toxicity of Andean blueberry, weakly bacteriostatic activity, and high contents of anthocyanins and antioxidant capacity, which were partially bioaccesible in vitro (~ 50 % at the final intestinal step), contributing to the knowledge of its health benefits for consumers and its potential use in the food and pharmaceutical industry as functional ingredient.


mortiño; Vaccinium floribundum; HPLC-MS/MS; anthocyanins; antioxidant; antimicrobial; toxicity; Zebrafish.



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