Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Risk of COVID-19 on Diabetes Mellitus and Hypertension

Version 1 : Received: 31 August 2020 / Approved: 2 September 2020 / Online: 2 September 2020 (05:37:46 CEST)

How to cite: Aborode, A.; Aiyenuro, A.; Ogunsola, S.; Adesewa, V.; Zakariyah, M. Risk of COVID-19 on Diabetes Mellitus and Hypertension. Preprints 2020, 2020090029 (doi: 10.20944/preprints202009.0029.v1). Aborode, A.; Aiyenuro, A.; Ogunsola, S.; Adesewa, V.; Zakariyah, M. Risk of COVID-19 on Diabetes Mellitus and Hypertension. Preprints 2020, 2020090029 (doi: 10.20944/preprints202009.0029.v1).

Abstract

The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), is causing substantial morbidity and mortality. Older age and presence of diabetes mellitus, hypertension and obesity significantly increases the risk for hospitalization and death in COVID-19 patients. In this Perspective, informed by the studies on SARS-CoV-2, Middle East respiratory syndrome (MERS-CoV), and the current literature on SARS-CoV-2, we discuss potential mechanisms by which diabetes modulates the host-viral interactions and host-immune responses. We hope to highlight gaps in knowledge that require further studies pertinent to COVID-19 in patients with diabetes mellitus, hypertension and obesity.

Subject Areas

diabetes mellitus; hypertension; obesity; Coronavirus; mechanism; COVID-19; viral interaction

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