Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Patterns in Protein Components Present in Rattlesnake Venom: A Meta-Analysis

Version 1 : Received: 30 August 2020 / Approved: 1 September 2020 / Online: 1 September 2020 (11:42:14 CEST)

How to cite: Deshwal, A.; Phan, P.; Kannan, R.; Thallapuranam, S.K. Patterns in Protein Components Present in Rattlesnake Venom: A Meta-Analysis. Preprints 2020, 2020090012 (doi: 10.20944/preprints202009.0012.v1). Deshwal, A.; Phan, P.; Kannan, R.; Thallapuranam, S.K. Patterns in Protein Components Present in Rattlesnake Venom: A Meta-Analysis. Preprints 2020, 2020090012 (doi: 10.20944/preprints202009.0012.v1).

Abstract

The specificity and potency of venom components gives them a unique advantage in development of various pharmaceutical drugs. Though venom is a cocktail of proteins rarely is the synergy and association between various venom components studied. Understanding the relationship between various components is critical in medical research. Using meta-analysis, we found underlying patterns and associations in the appearance of the toxin families. For Crotalus, Dis has the most associations with the following toxins: PDE; BPP; CRL; CRiSP; LAAO; SVMP P-I & LAAO; SVMP P-III and LAAO. In Sistrurus venom CTL and NGF had most associations. These associations can be used to predict presence of proteins in novel venom and to understand synergies between venom components for enhanced bioactivity. Using this approach, the need to revisit classification of proteins as major components or minor components is highlighted. The revised classification of venom components needs to be based on ubiquity, bioactivity, number of associations and synergies. The revised classification will help in increased research on venom components such as NGF which have high medical importance.

Subject Areas

Rattlesnake; Crotalus; Sistrurus; Venom; Toxin; Association

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