Working Paper Review Version 2 This version is not peer-reviewed

A Complex Systems Perspective on Neuroimaging Studies of Behaviour and Its Disorders

Version 1 : Received: 27 August 2020 / Approved: 30 August 2020 / Online: 30 August 2020 (10:53:32 CEST)
Version 2 : Received: 2 September 2020 / Approved: 2 September 2020 / Online: 2 September 2020 (10:02:03 CEST)

How to cite: Turkheimer, F.E.; Rosas, F.E.; Dipasquale, O.; Martins, D.; Fagerholm, E.D.; Expert, P.; Vasa, F.; Lord, L.; Leech, R. A Complex Systems Perspective on Neuroimaging Studies of Behaviour and Its Disorders. Preprints 2020, 2020080654 Turkheimer, F.E.; Rosas, F.E.; Dipasquale, O.; Martins, D.; Fagerholm, E.D.; Expert, P.; Vasa, F.; Lord, L.; Leech, R. A Complex Systems Perspective on Neuroimaging Studies of Behaviour and Its Disorders. Preprints 2020, 2020080654

Abstract

The study of complex systems deals with emergent behaviour that arises as a result of nonlinear spatio-temporal interactions between a large number of components both within the system, as well as between the system and its environment. There is a strong case to be made that neural systems as well as their emergent behaviour and disorders, can be studied within the framework of complexity science. In particular, the field of neuroimaging has begun to apply both theoretical and experimental procedures originating in complexity science – usually in parallel with traditional methodologies. Here, we demonstrate that the use of such traditional models may distort the outcomes of neuroimaging experiments – hence affecting their interpretability and raising questions about their reliability.Therefore, we argue in favor of adopting a complex systems-based methodology in the study of neuroimaging, alongside appropriate experimental paradigms, and with minimal influences from non-complex systems approaches. Our exposition includes a review of the fundamental mathematical concepts, combined with practical examples and a compilation of results from the literature.

Subject Areas

Complex systems; Emergence; Neuroimaging; Behaviour; Disorders

Comments (1)

Comment 1
Received: 2 September 2020
Commenter: Paul Expert
Commenter's Conflict of Interests: Author
Comment: I updated the author list so that the list on the preprint site matches the author list on the manuscript.
Please check against v1 that all authors added where on the original submission.
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