Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Canine Hemangiosarcoma: A Certainly Less Than Ideal, Very Ugly Cancer

Version 1 : Received: 21 August 2020 / Approved: 24 August 2020 / Online: 24 August 2020 (10:08:43 CEST)

How to cite: Tinsley, A. Canine Hemangiosarcoma: A Certainly Less Than Ideal, Very Ugly Cancer. Preprints 2020, 2020080528 (doi: 10.20944/preprints202008.0528.v1). Tinsley, A. Canine Hemangiosarcoma: A Certainly Less Than Ideal, Very Ugly Cancer. Preprints 2020, 2020080528 (doi: 10.20944/preprints202008.0528.v1).

Abstract

Canine Hemangiosarcoma (HSA) is a devastating cancer affecting blood vessels in numerous sites within the body that is primarily seen in middle to older aged dogs. It is marked by its rapid aggressive metastatic pathology that often results in a lack of apparent symptoms in early stages. In most cases, disease becomes apparent due to hemorrhagic events following the rupture of the malignant vascular cell structures that can capture and pool blood cells, resulting in necrosis of the affected tissues. The poor survival times in affected patients cause a hindrance to the ability to carry out large scale studies, leaving numerous knowledge gaps to be filled in future research. The pathologic similarities between this and human angiosarcoma (HA) provides the potential for translatable research to be carried out that would improve outcomes across species. Here, current knowledge is outlined in order to improve understanding HSA holistically and suggest future direction. Emphasis is placed on the potential to improve veterinary practices in ways that will improve the ability to quickly and accurately diagnose patients in order to establish better client communication and provide clarity in collaborating to create the best informed treatment plan possible.

Subject Areas

Hemangiosarcoma; neoplasia; oncology; metastasis; doxorubicin; hemoabdomen

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