Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Oxytocin Pathway Genes (CD38, OXTR) and Psychosocial Characteristics Defined According to Strengths and Difficulties Questionnaire in Urban Siberian Adolescents: A School-based Study

Version 1 : Received: 19 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (07:30:29 CEST)

How to cite: Tereshchenko, S.; Kasparov, E.; Zobova, S.; Smolnikova, M.; Evert, L.; Zaitseva, O.; Shubina, M.; Gorbacheva, N.; Lapteva, L.; Semenova, N. Oxytocin Pathway Genes (CD38, OXTR) and Psychosocial Characteristics Defined According to Strengths and Difficulties Questionnaire in Urban Siberian Adolescents: A School-based Study. Preprints 2020, 2020080439 (doi: 10.20944/preprints202008.0439.v1). Tereshchenko, S.; Kasparov, E.; Zobova, S.; Smolnikova, M.; Evert, L.; Zaitseva, O.; Shubina, M.; Gorbacheva, N.; Lapteva, L.; Semenova, N. Oxytocin Pathway Genes (CD38, OXTR) and Psychosocial Characteristics Defined According to Strengths and Difficulties Questionnaire in Urban Siberian Adolescents: A School-based Study. Preprints 2020, 2020080439 (doi: 10.20944/preprints202008.0439.v1).

Abstract

Oxytocin (OT) is regarded as an extremely important prosocial neuropeptide that dramatically affects the establishment of social connections from infancy to adulthood. OT effects on the psychoemotional state are pretty individual and may be dependent on age, gender, ethnocultural factors, social environment, the presence of stress factors, and features of personality. The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathological screening tool and is recommended for the detection and classification of psychosocial problems in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18) explored the relation of SDQ scales in relation to genotypes of CD38 gene that controls oxytocin release, rs3796863, and oxytocin receptor gene (OXTR), rs53576. The results of our study show that during the adolescence period, OT pathway high activity can cause some negative effects, such as emotional instability in young (aged 12–14) adolescent girls in the case of carriage of the rs3796863 A allele and emotional disturbances in older (aged 15–18) adolescent boys who are carriers of a GG variant of rs53576. Our results support the hypothesis of OT-mediated excessive social sensitivity which can lead to some age-sex depending psychosocial problems during adolescence.

Subject Areas

oxytocin; CD38; OXTR; rs3796863; rs53576; polymorphism; adolescents; psychosocial characteristics; Strengths and Difficulties Questionnaire

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