Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Oxytocin Pathway Genes (CD38, OXTR) and Psychosocial Characteristics Defined According to Strengths and Difficulties Questionnaire in Urban Siberian Adolescents: A School-based Study

Sergey Tereshchenko
* ORCID logo ,
Edward Kasparov
,
Svetlana Zobova
,
Marina Smolnikova
,
Lidia Evert
,
Olga Zaitseva
,
Margarita Shubina
,
Nina Gorbacheva
,
Ludmila Lapteva
,
Nadezhda Semenova
Version 1 : Received: 19 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (07:30:29 CEST)

A peer-reviewed article of this Preprint also exists.

Tereshchenko S, Kasparov E, Zobova S, Smolnikova M, Evert L, Semenova N, Zaitseva O, Shubina M, Gorbacheva N and Lapteva L (2021) Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study. Front. Psychiatry 12:714093. Tereshchenko S, Kasparov E, Zobova S, Smolnikova M, Evert L, Semenova N, Zaitseva O, Shubina M, Gorbacheva N and Lapteva L (2021) Oxytocin Pathway Gene (CD38, OXTR) Variants Are Not Related to Psychosocial Characteristics Defined by Strengths and Difficulties Questionnaire in Adolescents: A Field School-Based Study. Front. Psychiatry 12:714093.

Abstract

Oxytocin (OT) is regarded as an extremely important prosocial neuropeptide that dramatically affects the establishment of social connections from infancy to adulthood. OT effects on the psychoemotional state are pretty individual and may be dependent on age, gender, ethnocultural factors, social environment, the presence of stress factors, and features of personality. The Strengths and Difficulties Questionnaire (SDQ) is a brief psychopathological screening tool and is recommended for the detection and classification of psychosocial problems in adolescents. The current field school-based study, conducted among urban Siberian adolescents (n = 298 aged 12–18) explored the relation of SDQ scales in relation to genotypes of CD38 gene that controls oxytocin release, rs3796863, and oxytocin receptor gene (OXTR), rs53576. The results of our study show that during the adolescence period, OT pathway high activity can cause some negative effects, such as emotional instability in young (aged 12–14) adolescent girls in the case of carriage of the rs3796863 A allele and emotional disturbances in older (aged 15–18) adolescent boys who are carriers of a GG variant of rs53576. Our results support the hypothesis of OT-mediated excessive social sensitivity which can lead to some age-sex depending psychosocial problems during adolescence.

Keywords

oxytocin; CD38; OXTR; rs3796863; rs53576; polymorphism; adolescents; psychosocial characteristics; Strengths and Difficulties Questionnaire

Subject

Social Sciences, Behavior Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.