Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Sequence Analysis of Egyptian Foot-And-Mouth Disease Virus Field and Vaccine Strains: Intertypic Recombination and Evidence for Accidental Release of Virulent Virus

Version 1 : Received: 11 August 2020 / Approved: 12 August 2020 / Online: 12 August 2020 (11:56:33 CEST)

A peer-reviewed article of this Preprint also exists.

Abd El Rahman, S.; Hoffmann, B.; Karam, R.; El-Beskawy, M.; Hamed, M.F.; Forth, L.F.; Höper, D.; Eschbaumer, M. Sequence Analysis of Egyptian Foot-and-Mouth Disease Virus Field and Vaccine Strains: Intertypic Recombination and Evidence for Accidental Release of Virulent Virus. Viruses 2020, 12, 990. Abd El Rahman, S.; Hoffmann, B.; Karam, R.; El-Beskawy, M.; Hamed, M.F.; Forth, L.F.; Höper, D.; Eschbaumer, M. Sequence Analysis of Egyptian Foot-and-Mouth Disease Virus Field and Vaccine Strains: Intertypic Recombination and Evidence for Accidental Release of Virulent Virus. Viruses 2020, 12, 990.

Journal reference: Viruses 2020, 12, 990
DOI: 10.3390/v12090990

Abstract

In addition to the risk of vaccine failure caused by strain mismatch, the production of inactivated FMD vaccines is dangerous if adequate biosafety cannot be maintained. Using a high-throughput sequencing protocol optimized for short nucleic acid fragments, the composition of a local inactivated vaccine was analyzed in depth. The serotype O strain identified in the vaccine was genetically identical to viruses found in recent FMD outbreaks in Egypt.

Subject Areas

FMDV; Egypt; full-genome sequencing; interserotypic recombination; vaccine composition analysis; frozen evolution

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