Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Spectrum of Cardiovascular Complications in COVID-19- A Comprehensive Literature Review

Version 1 : Received: 8 August 2020 / Approved: 11 August 2020 / Online: 11 August 2020 (07:47:51 CEST)

How to cite: Mushtaque, R.S.; Mushtaque, R.; Baloch, S.; Raza, A.; Bhatti, H.; Khan, Z. The Spectrum of Cardiovascular Complications in COVID-19- A Comprehensive Literature Review. Preprints 2020, 2020080257 (doi: 10.20944/preprints202008.0257.v1). Mushtaque, R.S.; Mushtaque, R.; Baloch, S.; Raza, A.; Bhatti, H.; Khan, Z. The Spectrum of Cardiovascular Complications in COVID-19- A Comprehensive Literature Review. Preprints 2020, 2020080257 (doi: 10.20944/preprints202008.0257.v1).

Abstract

A newly identified novel coronavirus named as severe acute respiratory syndrome-related coronavirus2 (SARS‐CoV 2) has given rise to the global pandemic. SARS-CoV2 which causes coronavirus disease 2019 (COVID-19), is a positive-stranded RNA virus with nucleocapsid. It binds to host angiotensin-converting enzyme2 (ACE2) receptor through surface glycoprotein (S protein). These ACE 2 receptors are attached to the cell membranes of many organs. Thus, COVID-19 does not only result in acute respiratory distress syndrome but also affects multiple organ systems, requiring a multidisciplinary approach to manage this disease. COVID-19 can damage the myocardial cells and result in fulminant myocarditis, acute cardiac injury, cardiomyopathy, heart failure, cardiogenic shock, or arrhythmia. COVID-19 seeds harmful immune response through cytokine storm leading to indirect organ damage. In this literature review, the available data is comprehended regarding cardiovascular complications in COVID-19, and the correlation of biomarkers with the disease activity is discussed. This literature review also highlights the important treatment options and outcomes of the individual study.

Subject Areas

COVID-19; SARS-CoV2; Acute Cardiac Injury; Arrhythmia; Heart Failure; Cardiogenic Shock

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