Hypothesis
Version 1
Preserved in Portico This version is not peer-reviewed
Household Representative Sample Strategy for COVID-19 Large-Scale Population Screening
Version 1
: Received: 31 July 2020 / Approved: 2 August 2020 / Online: 2 August 2020 (12:48:19 CEST)
A peer-reviewed article of this Preprint also exists.
Abstract
In the advent of COVID-19 pandemic, testing is highly essential to be able to isolate, treat infected persons, and finally curb transmission of this infectious respiratory disease. Group testing has been used previously for various infectious diseases and recently reported for large-scale population testing of COVID-19. However, possible sample dilution as a result of large pool sizes has been reported, limiting testing methods’ detection sensitivity. Moreover, the need to sample all individuals prior to pooling overburden the limited resources such as test kits. An alternative proposed strategy where test is performed on pooled samples from individuals representing different households is presented here. This strategy intends to improve group testing method through the reduction in the number of samples collected and pooled during large-scale population testing. Moreover, it introduces database system which enables continuous monitoring of the population’s virus exposure for better decision making.
Keywords
COVID-19; group testing; household; screening
Subject
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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