Measuring and Modelling the Epithelial Mesenchymal Hybrid State in Cancer: Clinical Implications

Mohit Kumar Jolly; Ryan J. Murphy; Sugandha Bhatia; Holly J. Whitfield; Andrew Redfern; Melissa J. Davis; Erik W. Thompson

Working Paper Review Version 2 This version is not peer-reviewed

Version 1 : Received: 31 July 2020 / Approved: 2 August 2020 / Online: 2 August 2020 (12:07:34 CEST)
Version 2 : Received: 10 February 2021 / Approved: 10 February 2021 / Online: 10 February 2021 (15:04:19 CET)

The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques.

epithelial mesenchymal plasticity (EMP); epithelial mesenchymal transition (EMT); mesenchymal epithelial transition (MET); E/M Hybrid; partial EMT; computational biology; mathematical modeling; cancer

Biology and Life Sciences, Anatomy and Physiology

Comment 1

Received: 10 February 2021
Commenter: Mohit Kumar Jolly
Commenter's Conflict of Interests: Author

Comment: More relevant studies, especially from a clinical perspective, have been now included.

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Measuring and Modelling the Epithelial Mesenchymal Hybrid State in Cancer: Clinical Implications

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