Working Paper Review Version 2 This version is not peer-reviewed

Measuring and Modelling the Epithelial Mesenchymal Hybrid State in Cancer: Clinical Implications

Version 1 : Received: 31 July 2020 / Approved: 2 August 2020 / Online: 2 August 2020 (12:07:34 CEST)
Version 2 : Received: 10 February 2021 / Approved: 10 February 2021 / Online: 10 February 2021 (15:04:19 CET)

How to cite: Jolly, M.K.; Murphy, R.J.; Bhatia, S.; Whitfield, H.J.; Redfern, A.; Davis, M.J.; Thompson, E.W. Measuring and Modelling the Epithelial Mesenchymal Hybrid State in Cancer: Clinical Implications. Preprints 2020, 2020080023 Jolly, M.K.; Murphy, R.J.; Bhatia, S.; Whitfield, H.J.; Redfern, A.; Davis, M.J.; Thompson, E.W. Measuring and Modelling the Epithelial Mesenchymal Hybrid State in Cancer: Clinical Implications. Preprints 2020, 2020080023

Abstract

The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques.

Keywords

epithelial mesenchymal plasticity (EMP); epithelial mesenchymal transition (EMT); mesenchymal epithelial transition (MET); E/M Hybrid; partial EMT; computational biology; mathematical modeling; cancer

Comments (1)

Comment 1
Received: 10 February 2021
Commenter: Mohit Kumar Jolly
Commenter's Conflict of Interests: Author
Comment: More relevant studies, especially from a clinical perspective, have been now included.
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