Preprint Review Version 1 This version is not peer-reviewed

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

Version 1 : Received: 15 July 2020 / Approved: 17 July 2020 / Online: 17 July 2020 (09:26:21 CEST)

How to cite: Patrulea, V.; Borchard, G.; Jordan, O. An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections. Preprints 2020, 2020070375 (doi: 10.20944/preprints202007.0375.v1). Patrulea, V.; Borchard, G.; Jordan, O. An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections. Preprints 2020, 2020070375 (doi: 10.20944/preprints202007.0375.v1).

Abstract

Bacterial infections occur when wound healing fails to reach the final stage of healing, usually hindered by the presence of different pathogens. Different topical antimicrobial agents are used to inhibit bacterial growth due to antibiotic failure in reaching the infected site accompanied very often by an increased drug resistance and other side effects. In this review, we focus on antimicrobial peptides (AMPs), especially those with a high potential of efficacy against multidrug-resistant and biofilm-forming bacteria and fungi present in wound infections. Currently, different AMPs undergo preclinical and clinical phase to combat infection-related diseases. AMP dendrimers (AMPDs) have been mentioned as potent microbial agents. Various AMP delivery strategies, such as polymers, scaffolds, films and wound dressings, organic and inorganic nanoparticles, to combat infection and modulate the healing rate have been discussed as well. New technologies such as CRISPR-Cas are taken into consideration as potential future tools for AMP delivery in skin therapy.

Subject Areas

bacterial infection; non-healing wounds; antimicrobial resistance; multidrug resistance; antimicrobial peptides (AMPs); AMP conjugates; AMP carriers and delivery systems

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