Version 1
: Received: 16 July 2020 / Approved: 16 July 2020 / Online: 16 July 2020 (12:52:03 CEST)
How to cite:
Kent, J.; Obi, P.; Jeyaraman, M.; Askin, N.; Pierdoná, T.; Halayko, A.; Saleem, A. The Therapeutic Effect of Extracellular Vesicles on Asthma in Pre-clinical Models: A Systematic Review Protocol. Preprints2020, 2020070349. https://doi.org/10.20944/preprints202007.0349.v1
Kent, J.; Obi, P.; Jeyaraman, M.; Askin, N.; Pierdoná, T.; Halayko, A.; Saleem, A. The Therapeutic Effect of Extracellular Vesicles on Asthma in Pre-clinical Models: A Systematic Review Protocol. Preprints 2020, 2020070349. https://doi.org/10.20944/preprints202007.0349.v1
Kent, J.; Obi, P.; Jeyaraman, M.; Askin, N.; Pierdoná, T.; Halayko, A.; Saleem, A. The Therapeutic Effect of Extracellular Vesicles on Asthma in Pre-clinical Models: A Systematic Review Protocol. Preprints2020, 2020070349. https://doi.org/10.20944/preprints202007.0349.v1
APA Style
Kent, J., Obi, P., Jeyaraman, M., Askin, N., Pierdoná, T., Halayko, A., & Saleem, A. (2020). The Therapeutic Effect of Extracellular Vesicles on Asthma in Pre-clinical Models: A Systematic Review Protocol. Preprints. https://doi.org/10.20944/preprints202007.0349.v1
Chicago/Turabian Style
Kent, J., Andrew Halayko and Ayesha Saleem. 2020 "The Therapeutic Effect of Extracellular Vesicles on Asthma in Pre-clinical Models: A Systematic Review Protocol" Preprints. https://doi.org/10.20944/preprints202007.0349.v1
Abstract
Asthma is the most common chronic disease in children. It is characterized by difficulty in breathing and chronic airway inflammation associated with narrowing of the airways, and airway hyperresponsiveness. If left untreated, asthma can lead to respiratory distress and even death. A number of medications are available and prescribed to manage asthma. Yet despite that, only half of the asthmatic patients are able to control their condition. Extracellular vesicles (EVs) play an important role in transporting contents such as nucleic acids, proteins, and lipids to other cells. While EVs have been extensively studied as biomarkers of various pathological states, evidence indicates that they can play protective and therapeutic roles in mitigating diseases such as cancer, cardiovascular disease and asthma. Here we propose to conduct a systematic review that provides a detailed analysis of the therapeutic effect of EVs in mitigating the primary (inflammation, airway hyperresponsiveness) and secondary outcomes (airway remodelling, molecular indices of cellular signalling, and inflammatory mediators in serum) associated with asthma in preclinical studies.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
