Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Therapeutic Effect of Extracellular Vesicles on Asthma in Pre-clinical Models: A Systematic Review Protocol

Version 1 : Received: 16 July 2020 / Approved: 16 July 2020 / Online: 16 July 2020 (12:52:03 CEST)

How to cite: Kent, J.; Obi, P.; Jeyaraman, M.; Askin, N.; Pierdoná, T.; Halayko, A.; Saleem, A. The Therapeutic Effect of Extracellular Vesicles on Asthma in Pre-clinical Models: A Systematic Review Protocol. Preprints 2020, 2020070349 (doi: 10.20944/preprints202007.0349.v1). Kent, J.; Obi, P.; Jeyaraman, M.; Askin, N.; Pierdoná, T.; Halayko, A.; Saleem, A. The Therapeutic Effect of Extracellular Vesicles on Asthma in Pre-clinical Models: A Systematic Review Protocol. Preprints 2020, 2020070349 (doi: 10.20944/preprints202007.0349.v1).

Abstract

Asthma is the most common chronic disease in children. It is characterized by difficulty in breathing and chronic airway inflammation associated with narrowing of the airways, and airway hyperresponsiveness. If left untreated, asthma can lead to respiratory distress and even death. A number of medications are available and prescribed to manage asthma. Yet despite that, only half of the asthmatic patients are able to control their condition. Extracellular vesicles (EVs) play an important role in transporting contents such as nucleic acids, proteins, and lipids to other cells. While EVs have been extensively studied as biomarkers of various pathological states, evidence indicates that they can play protective and therapeutic roles in mitigating diseases such as cancer, cardiovascular disease and asthma. Here we propose to conduct a systematic review that provides a detailed analysis of the therapeutic effect of EVs in mitigating the primary (inflammation, airway hyperresponsiveness) and secondary outcomes (airway remodelling, molecular indices of cellular signalling, and inflammatory mediators in serum) associated with asthma in preclinical studies.

Subject Areas

systematic review; extracellular vesicles; EVs; asthma; therapy; inflammation; respiratory disease; airway hyperresponsiveness; BALF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.