Working Paper Article Version 1 This version is not peer-reviewed

COVID-19: Role of the Inflammasome

Version 1 : Received: 11 July 2020 / Approved: 12 July 2020 / Online: 12 July 2020 (08:17:56 CEST)

How to cite: Gallo, C.G.; Fiorino, S.; Posabella, G.; Antonacci, D.; Tropeano, A.; Pausini, E.; Pausini, C.; Guarniero, T.; Zancanaro, M. COVID-19: Role of the Inflammasome. Preprints 2020, 2020070246 Gallo, C.G.; Fiorino, S.; Posabella, G.; Antonacci, D.; Tropeano, A.; Pausini, E.; Pausini, C.; Guarniero, T.; Zancanaro, M. COVID-19: Role of the Inflammasome. Preprints 2020, 2020070246

Abstract

Covid-19 disease is caused by SARS Cov-2 virus. Despite its high transmissibility, the CFR (Case Fatality Rate) of COVID-19 seems to be lower than the SARS (9,5%) and MERS (34,4%) ones93 , but higher than the influenza one (0-1%)94,95 . The disease is asymptomatic or paucisymptomatic in most of the patients, although in few cases it can be characterized by serious complications. The main causes of hospitalization in intensive care are represented by ALI (Acute Lung Injury), ARDS (Acute Respiratory Distress Syndrome), cardiovascular problems and coagulopathies (diffuse thrombosis, microthrombosis, embolisms, myocarditis, arrhytmias, heart failure, stroke)96-98, acute nephropathy99,100 and encephalopathies101. The virus presence in the vascular wall can cause endotheliitis, which triggers the process of diffuse coagulation that can lead to a worsening of the systemic inflammation. The exaggerated inflammatory response seems to be connected with the development of ARDS, MOF (Multiple Organ Failure) and coagulopathies102-107.

Subject Areas

COVID-19; Inflammasome; Interleukin 1β; Inflammation; Innate Immune System

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