Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

An Updated Overview of the Neurophysiological and Psychosocial Dimensions of Fibromyalgia – A Call for an Integrative Model

Ana Margarida Pinto
* ,
Rinie Geenen
,
Filipe Palavra
,
Mark A. Lumley
,
Jacob N. Ablin
,
Kirstine Amris
,
Jaime Branco
ORCID logo ,
Dan Buskila
,
Miguel Castelo-Branco
,
Leslie J. Crofford
,
Mary-Ann Fitzcharles
,
Mariana Luís
,
Tiago Reis Marques
,
Jamie L. Rhudy
,
Lucina Q. Uddin
,
Paula Castilho
,
Johannes W. G. Jacobs
,
José A. P. da Silva
Version 1 : Received: 10 July 2020 / Approved: 11 July 2020 / Online: 11 July 2020 (03:45:54 CEST)

How to cite: Pinto, A.M.; Geenen, R.; Palavra, F.; Lumley, M.A.; Ablin, J.N.; Amris, K.; Branco, J.; Buskila, D.; Castelo-Branco, M.; Crofford, L.J.; Fitzcharles, M.; Luís, M.; Reis Marques, T.; Rhudy, J.L.; Uddin, L.Q.; Castilho, P.; Jacobs, J.W.G.; da Silva, J.A.P. An Updated Overview of the Neurophysiological and Psychosocial Dimensions of Fibromyalgia – A Call for an Integrative Model. Preprints 2020, 2020070224. https://doi.org/10.20944/preprints202007.0224.v1 Pinto, A.M.; Geenen, R.; Palavra, F.; Lumley, M.A.; Ablin, J.N.; Amris, K.; Branco, J.; Buskila, D.; Castelo-Branco, M.; Crofford, L.J.; Fitzcharles, M.; Luís, M.; Reis Marques, T.; Rhudy, J.L.; Uddin, L.Q.; Castilho, P.; Jacobs, J.W.G.; da Silva, J.A.P. An Updated Overview of the Neurophysiological and Psychosocial Dimensions of Fibromyalgia – A Call for an Integrative Model. Preprints 2020, 2020070224. https://doi.org/10.20944/preprints202007.0224.v1

Abstract

Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia (FM) has progressed remarkably in recent years. Despite this, currents accounts of FM fail to capture the complex, dynamic and mutual crosstalk between neurophysiological and psychosocial domains. We conducted a comprehensive review of the existing literature in order to synthesise current knowledge on FM, explore and highlight multi-level links and pathways among different systems and build bridges between existing approaches. An extensive panel of international experts in neurophysiology and psychosocial aspects of FM discussed the collected evidence and progressively refined and conceptualized its interpretation. Fibromyalgia is a complex condition resulting from the dynamic interplay between multiple systems and processes. We provided an updated overview of the most relevant observations in FM to date as well as the potential pathways by which they exert they are related and exert their mutual influence, to produce the manifestations commonly associated with FM. This review constituted the first step towards and supported the development of a much needed model capable of integrating the main factors implicated in FM into a single, unified model that may prove valuable in understanding and managing FM.

Keywords

fibromyalgia; comprehensive review; neurophysiological abnormalities; psychosocial processes; integration

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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