Version 1
: Received: 7 July 2020 / Approved: 10 July 2020 / Online: 10 July 2020 (01:57:16 CEST)
How to cite:
Mohanta, T.K.; Sharma, N.; Arina, P.; Defilippi, P. Molecular Insights on Potential Combination of Mapk Inhibitors Together with HCQ and HCQs Analogs in Viral Infection. Preprints2020, 2020070201. https://doi.org/10.20944/preprints202007.0201.v1
Mohanta, T.K.; Sharma, N.; Arina, P.; Defilippi, P. Molecular Insights on Potential Combination of Mapk Inhibitors Together with HCQ and HCQs Analogs in Viral Infection. Preprints 2020, 2020070201. https://doi.org/10.20944/preprints202007.0201.v1
Mohanta, T.K.; Sharma, N.; Arina, P.; Defilippi, P. Molecular Insights on Potential Combination of Mapk Inhibitors Together with HCQ and HCQs Analogs in Viral Infection. Preprints2020, 2020070201. https://doi.org/10.20944/preprints202007.0201.v1
APA Style
Mohanta, T.K., Sharma, N., Arina, P., & Defilippi, P. (2020). Molecular Insights on Potential Combination of Mapk Inhibitors Together with HCQ and HCQs Analogs in Viral Infection. Preprints. https://doi.org/10.20944/preprints202007.0201.v1
Chicago/Turabian Style
Mohanta, T.K., Pietro Arina and Paola Defilippi. 2020 "Molecular Insights on Potential Combination of Mapk Inhibitors Together with HCQ and HCQs Analogs in Viral Infection" Preprints. https://doi.org/10.20944/preprints202007.0201.v1
Abstract
The outbreak of coronavirus disease-19 (COVID-19) has infected more than 11 million people and has claimed more than 530.000 deaths world-wide. In July 2020, still, there is no specific treatment for disease caused by the novel coronavirus. In the search to curb the global pandemic COVID-19, some eastern and developing countries have approved various treatment with controversial efficacy, among that the use of the antimalarial Hydroxychloroquine (HCQ), so far with inconclusive clinical evidence of effectiveness. On the other hand, computer-based screening suggest that HCQs analog are promising molecules, to impair viral replication in vitro[1]. Therefore, what is emerging from this complex background, is the need to understand molecular mechanism beyond drugs that can be helpful against viral infection for this and future pandemic. The intent of this Brief Report is to highlight: i) the involvement of the Mitogen Activated Protein Kinase (MAPK) cascade in viral infection and ii) the urgent need to have molecular data on the effectiveness of the combination of MAPK inhibitors together with HCQ and HCQs analogs in curbing viral infection. We are convinced that a better understanding of the patterns of elicited molecular mechanisms will be critical for new molecular approaches to this severe disease
Keywords
MAPK cascade; viral infection; HCQ
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
