Working Paper Article Version 1 This version is not peer-reviewed

A Novel Clinical Research Modality for Enrolling Diverse Participants Using a Diverse Team

Version 1 : Received: 6 July 2020 / Approved: 7 July 2020 / Online: 7 July 2020 (04:42:39 CEST)

How to cite: Lay, P.; Paralkar, T.; Ahmed, S.H.; Ghani, M.; Muneer, S.; Jinnah, R.; Chen, C.; Zeitz, J.; Nitsch, A.; Osier, N.(. A Novel Clinical Research Modality for Enrolling Diverse Participants Using a Diverse Team. Preprints 2020, 2020070110 Lay, P.; Paralkar, T.; Ahmed, S.H.; Ghani, M.; Muneer, S.; Jinnah, R.; Chen, C.; Zeitz, J.; Nitsch, A.; Osier, N.(. A Novel Clinical Research Modality for Enrolling Diverse Participants Using a Diverse Team. Preprints 2020, 2020070110

Abstract

The advancement of the pediatric traumatic brain injury (TBI) knowledge base requires biospecimens and data from large samples. This study seeks to describe a novel clinical research modality to establish best practices for enrolling a diverse pediatric TBI population and quantifying key information on enrollment into biobanks. Screening form responses were standardized and cleaned through Google Sheets. Data was used to analyze total individuals at each enrollment stage. R was utilized for final analysis, including chi-square goodness of fit and proportion statistical tests, to determine further significance and relationships. Issues throughout data cleaning shed light on limitations of the consent modality. Results suggest that through a diverse research team, the recruited sample exceeds traditional measures of representation (e.g. sex, race, ethnicity). Sex demographics of the study are representative of the local population. Screening for candidates is critical to the success of the consent modality. The consent modality may be modified to increase diversity of study population and accept bilingual candidates. Researchers must implement best practices, including increasing inclusivity of bilingual populations, utilizing technology, and improving participant follow-up, to improve health disparities for understudied clinical populations.

Subject Areas

brain injuries; traumatic brain injury; children; diversity; student-led; participant-focused; recruitment; sample; methods

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