Preprint Review Version 1 This version is not peer-reviewed

Mechanism of Vascular Endothelial Dysfunction Causing Arteriosclerosis: Vascular Endothelial Glycocalyx

Version 1 : Received: 5 July 2020 / Approved: 6 July 2020 / Online: 6 July 2020 (09:08:34 CEST)

How to cite: Yamaoka-Tojo, M. Mechanism of Vascular Endothelial Dysfunction Causing Arteriosclerosis: Vascular Endothelial Glycocalyx. Preprints 2020, 2020070099 (doi: 10.20944/preprints202007.0099.v1). Yamaoka-Tojo, M. Mechanism of Vascular Endothelial Dysfunction Causing Arteriosclerosis: Vascular Endothelial Glycocalyx. Preprints 2020, 2020070099 (doi: 10.20944/preprints202007.0099.v1).

Abstract

In atherosclerosis patients, vascular endothelial dysfunction is commonly observed with damage of vascular endothelial glycocalyx, an extracellular matrix-bound to and encapsulating the endothelial cell lining the blood vessel wall. Unfavorable lifestyle; smoking and physical inactivity, also induces glycocalyx degradation. Moreover, the vascular endothelial glycocalyx is damaged by various unfavorable disease conditions like as dehydration, acute infectious disease, trauma, sepsis, ARDS, Kawasaki disease, preeclampsia, gestational diabetes mellitus, hypertension, diabetes, chronic kidney disease, atherosclerosis, stroke, dementia, microvascular angina, acute coronary syndrome, and heart failure. The vascular endothelial glycocalyx has been shown to be important not only as a physical cytoprotective barrier for vascular endothelial cells but also as a mechanism that regulates intracellular cell signaling. Therefore, vascular endothelial glycocalyx has great potential to explore new strategies for assessing the benefit conditions of our healthy vasculature.

Subject Areas

vascular endothelial function; inflammation; oxidative stress; cardiovascular disease prevention; disease management

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