Version 1
: Received: 30 June 2020 / Approved: 3 July 2020 / Online: 3 July 2020 (05:54:18 CEST)
How to cite:
Mehboob, R.; Ahmad, F.J. SARS-Corona Virus-2 May Initially Infect Brainstem through Trigeminal Ganglion-Latency May Be Present-A New Perspective . Preprints2020, 2020070015. https://doi.org/10.20944/preprints202007.0015.v1
Mehboob, R.; Ahmad, F.J. SARS-Corona Virus-2 May Initially Infect Brainstem through Trigeminal Ganglion-Latency May Be Present-A New Perspective . Preprints 2020, 2020070015. https://doi.org/10.20944/preprints202007.0015.v1
Mehboob, R.; Ahmad, F.J. SARS-Corona Virus-2 May Initially Infect Brainstem through Trigeminal Ganglion-Latency May Be Present-A New Perspective . Preprints2020, 2020070015. https://doi.org/10.20944/preprints202007.0015.v1
APA Style
Mehboob, R., & Ahmad, F.J. (2020). <strong>SARS-Corona Virus-2 May Initially Infect Brainstem through Trigeminal Ganglion-Latency May Be Present-A New Perspective </strong>. Preprints. https://doi.org/10.20944/preprints202007.0015.v1
Chicago/Turabian Style
Mehboob, R. and Fridoon Jawad Ahmad. 2020 "<strong>SARS-Corona Virus-2 May Initially Infect Brainstem through Trigeminal Ganglion-Latency May Be Present-A New Perspective </strong>" Preprints. https://doi.org/10.20944/preprints202007.0015.v1
Abstract
Novel severe acute respiratory syndrome coronavirus 2 infection (SARS-Cov-2) is an acute respiratory and infectious disease. This perspective aims to provide the basic understanding of the inflammation caused by SARS-Cov-2 and relation to trigeminal ganglion (TG). Virus enters through the mucous membranes of orofacial region and reach the TG where it resides and take control of its peptides including Substance P (SP).SP is the main neuropeptide, neuromodulator and neuro-hormone of TG, associated with nociception and inflammation under noxious stimulus. SP release is triggered and consequently, it affects the immune cells, blood vessels to release the mediators for inflammation. Cytokine storming is initiated and cause respiratory distress, bronchoconstriction and death in complicated cases. Neurokinin-1 Receptor (NK-1R) antagonist and glucocorticoids may be used to alleviate the symptoms and treat this infection. SP is the main culprit seem to be involved in the triggering of inflammatory pathways in SARS-Cov-2 infection. It has direct association with cardiorespiratory rhythm, sleep-wake cycle, nociception, ventilator responses and regulates many important physiological and pathological roles. Its over-secretion should be blocked by NK-1R antagonist. However, experimental work leading to clinical trials are mandatory for further confirmation.
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
