Preprint Review Version 1 This version is not peer-reviewed

New Coronavirus Disease (COVID-19): Clinical Symptoms Other Than Pneumonia with Emphasis on Thrombosis

Version 1 : Received: 17 June 2020 / Approved: 28 June 2020 / Online: 28 June 2020 (10:34:52 CEST)

How to cite: Hayashi, T.; Abiko, K.; Mandai, M.; Yaegashi, N.; Konishi, I. New Coronavirus Disease (COVID-19): Clinical Symptoms Other Than Pneumonia with Emphasis on Thrombosis. Preprints 2020, 2020060339 (doi: 10.20944/preprints202006.0339.v1). Hayashi, T.; Abiko, K.; Mandai, M.; Yaegashi, N.; Konishi, I. New Coronavirus Disease (COVID-19): Clinical Symptoms Other Than Pneumonia with Emphasis on Thrombosis. Preprints 2020, 2020060339 (doi: 10.20944/preprints202006.0339.v1).

Abstract

The main manifestation of new coronavirus disease 2019 (COVID-19) is respiratory disease. The new coronavirus (SARS-CoV-2) attacks the lungs and may result in severe acute respiratory syndrome. In such cases, the infected person has difficulty breathing, which impairs oxygen uptake in the body. If pneumonia or another respiratory illness develops, and the host immune system is unable to combat SARS-CoV-2, the infected person may eventually die. Meanwhile, reports on unexpected symptoms in organs other than the nasal cavity, throat, and lungs are emerging. To elucidate the causes of such symptoms, we analyzed the expression status of angiotensin-converting enzyme 2 (ACE2), the host receptor used by SARS-CoV-2, in various tissues. This study confirmed that alveolar macrophages appear to be involved in pneumonitis and thrombus formation. In this report, we introduce some new symptoms.

Subject Areas

ACE2; COVID-19; SARS-CoV-2; alveolar macrophage; thrombus; thrombosis

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