Brief Report
Version 1
Preserved in Portico This version is not peer-reviewed
CD44 Alternative Splice Variants v6 and v10
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Version 1
: Received: 18 June 2020 / Approved: 21 June 2020 / Online: 21 June 2020 (10:45:09 CEST)
How to cite: Aquib, A.; Yadav, A. K. CD44 Alternative Splice Variants v6 and v10. Preprints 2020, 2020060255. https://doi.org/10.20944/preprints202006.0255.v1 Aquib, A.; Yadav, A. K. CD44 Alternative Splice Variants v6 and v10. Preprints 2020, 2020060255. https://doi.org/10.20944/preprints202006.0255.v1
Abstract
CD44 glycoprotein is ubiqutously present and situated at the extracellular surface of cell. Its role as an adhesion recptor was modified depending upon the state of post addition of glycomoeties under varied microenvironment. Many alternative spliced variants of CD44 were expressed by human cells depending upon the attainment during mutifunctional signal disposition. The function of splice factors, and hnRNPA family (Heterogenous ribonucleoproteins A) were dicussed in context to CD44 alternative variants. Glioma cell cline U87 MG were used in this study to search more about the affect of hnRNPA1 and hnRNPA2/B1 knockdown in CD44 V6 and CD44V10 expression. We found in preliminary study that splice factor knock down reduces the alternative splice variants of CD44 such as V6 & V10. Therefore, potential of this study to elaborate further the mechanism in vivo model, to validate the alternative spliced variant in context to interaction with extracellular microenvironment.
Keywords
U87MG; CD44; splice factor
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (2)
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Commenter: Rizwanul Haque
The commenter has declared there is no conflict of interests.
This is important piece of information about the splicing of CD44 that is one of the marker of cells. Different ispforms of CD 44 is important in the identification of different types of immune cells such as naive vs effector cells. This is a usefulanuscript for scientific community.
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The commenter has declared there is no conflict of interests.