PreprintHypothesisVersion 1Preserved in Portico This version is not peer-reviewed
Is Platelet-Activating Factor (PAF) a Missing Link for Elucidating the Mechanism of Action of the Coronavirus SARS-CoV-2 and Explaining the Side Effects-Complications of COVID-19 Disease?
Version 1
: Received: 19 June 2020 / Approved: 21 June 2020 / Online: 21 June 2020 (10:27:22 CEST)
How to cite:
Demopoulos, C.A. Is Platelet-Activating Factor (PAF) a Missing Link for Elucidating the Mechanism of Action of the Coronavirus SARS-CoV-2 and Explaining the Side Effects-Complications of COVID-19 Disease?. Preprints2020, 2020060253. https://doi.org/10.20944/preprints202006.0253.v1
Demopoulos, C.A. Is Platelet-Activating Factor (PAF) a Missing Link for Elucidating the Mechanism of Action of the Coronavirus SARS-CoV-2 and Explaining the Side Effects-Complications of COVID-19 Disease?. Preprints 2020, 2020060253. https://doi.org/10.20944/preprints202006.0253.v1
Demopoulos, C.A. Is Platelet-Activating Factor (PAF) a Missing Link for Elucidating the Mechanism of Action of the Coronavirus SARS-CoV-2 and Explaining the Side Effects-Complications of COVID-19 Disease?. Preprints2020, 2020060253. https://doi.org/10.20944/preprints202006.0253.v1
APA Style
Demopoulos, C.A. (2020). Is Platelet-Activating Factor (PAF) a Missing Link for Elucidating the Mechanism of Action of the Coronavirus SARS-CoV-2 and Explaining the Side Effects-Complications of COVID-19 Disease?. Preprints. https://doi.org/10.20944/preprints202006.0253.v1
Chicago/Turabian Style
Demopoulos, C.A. 2020 "Is Platelet-Activating Factor (PAF) a Missing Link for Elucidating the Mechanism of Action of the Coronavirus SARS-CoV-2 and Explaining the Side Effects-Complications of COVID-19 Disease?" Preprints. https://doi.org/10.20944/preprints202006.0253.v1
Abstract
Purpose of this article is to project from the point of view of the scientific data concerning PAF and as a new approach by involving PAF, in order to contribute to clarification and proposal a possible mechanism of action of the coronavirusSARS-CoV-2 and to give a possible explanation for its observed side effects-complications of Covid-19 disease. The article is not intended to suggest any specific drugs, but clarifying the mechanism is the first step in illuminating the direction of prescribing the targets of medication that may be appropriate for the prevention, treatment, and cure of Covid-19 disease. More specifically, the purpose of this article is to provide unequivocal evidence indicating that:1 It would not be unexpected for PAFR to participate in the entry of coronavirus SARS-CoV-2 into the cell. 2 There is interdependence and relationship of the receptors ACER and PAFR, which means the involvement of PAF in the processes related to coronavirus SARS-CoV-2 as well as to its effects exercised by the coronavirus SARS-CoV-2.3 The receptors ACER, PAFR and TLRs are also involved in inflammation as well as in virus binding to stabilize and enter into the cell, and so they are "communicating vessels" with PAF being " a missing link" 4 Consequently there is a correlations of COVID-19 disease manifestations and biological characteristics with those caused by PAF, which shows the involvement of PAF in COVID-19 disease.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
