Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Probiotics Effect on the Immune System

Version 1 : Received: 20 June 2020 / Approved: 21 June 2020 / Online: 21 June 2020 (10:07:31 CEST)

How to cite: Ng, J.C.K. Probiotics Effect on the Immune System. Preprints 2020, 2020060248. Ng, J.C.K. Probiotics Effect on the Immune System. Preprints 2020, 2020060248.


Background: Probiotics can provide health benefits to an individual by regulation of the immune system. Many clinical trials have found that probiotics can prevent upper respiratory tracts infections. Aim: To perform a systematic review and meta-analysis of available trials to investigate the effectiveness of probiotics in the prevention of upper respiratory tract infections in individuals of all ages. Conclusion: Probiotics were found to be better in reducing the number of participants who experienced acute URTI, the average duration per episode of acute URTI, use of antibiotics in URTI related cases and absence due to URTI. Side effects were found to be minor, making probiotics a good candidate for clinical use. This shows that probiotics are effective in preventing acute URTIs. However, due to limited studies and small sample size, the results are subjected to bias and should be interpreted with care.


probiotic; upper respiratory tract infection (URTI); infection; prevention; common cold


Biology and Life Sciences, Immunology and Microbiology

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