Preprint Article Version 1 This version is not peer-reviewed

Synthesis, Characterization and Biological Evaluation of Novel Tetrasubsituted Imidazole Compounds

Version 1 : Received: 16 June 2020 / Approved: 17 June 2020 / Online: 17 June 2020 (13:18:37 CEST)

How to cite: Shahzad, K.; Abbas, F.; PANDEY, D.; Ajmal, S.; Khadim, M.; Tahir, M.U. Synthesis, Characterization and Biological Evaluation of Novel Tetrasubsituted Imidazole Compounds. Preprints 2020, 2020060219 (doi: 10.20944/preprints202006.0219.v1). Shahzad, K.; Abbas, F.; PANDEY, D.; Ajmal, S.; Khadim, M.; Tahir, M.U. Synthesis, Characterization and Biological Evaluation of Novel Tetrasubsituted Imidazole Compounds. Preprints 2020, 2020060219 (doi: 10.20944/preprints202006.0219.v1).

Abstract

A new class of tetrasubstituted imidazole based compounds was synthesized using a multicomponent one-pot synthesis scheme through a cyclo condensation reaction of benzil, aromatic primary amines, aldehydes and ammonium acetate in glacial acetic acid. The synthesized compounds have been analyzed and characterized by melting point, color, conductivity method, CHN analysis, FT-IR, and UV-Visible. The reaction proceeding was examined by TLC after regular intervals of period. To test biological activity, the synthesized compounds have been examined against various bacterial strains. From the analysis of the antibacterial activity of these synthesized compounds demonstrated that all three imidazole compounds have considerable to significant activity against the strains, and compound K2 was found potent comparatively.

Subject Areas

tetrasubsituted imidazoles; synthesis; cyclocondensation reaction; characterization; antibacterial activity; compound K2

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