Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Assessment of Liver Metastases Using CT and MRI Scans in Patients with Pancreatic Ductal Adenocarcinoma: Effects of Observer Experience on Diagnostic Accuracy

Masakatsu Tsurusaki
* ORCID logo ,
Isao Numoto
,
Teruyoshi Oda
,
Miyuki Wakana
,
Ayako Suzuki
,
Yukinobu Yagyu
,
Mitsuru Matsuki
,
Kazunari Ishii
Version 1 : Received: 30 May 2020 / Approved: 31 May 2020 / Online: 31 May 2020 (18:32:40 CEST)

A peer-reviewed article of this Preprint also exists.

Tsurusaki, M.; Numoto, I.; Oda, T.; Wakana, M.; Suzuki, A.; Yagyu, Y.; Matsuki, M.; Ishii, K. Assessment of Liver Metastases Using CT and MRI Scans in Patients with Pancreatic Ductal Adenocarcinoma: Effects of Observer Experience on Diagnostic Accuracy. Cancers 2020, 12, 1455. Tsurusaki, M.; Numoto, I.; Oda, T.; Wakana, M.; Suzuki, A.; Yagyu, Y.; Matsuki, M.; Ishii, K. Assessment of Liver Metastases Using CT and MRI Scans in Patients with Pancreatic Ductal Adenocarcinoma: Effects of Observer Experience on Diagnostic Accuracy. Cancers 2020, 12, 1455.

Abstract

To investigate the impact of radiologic experience on the diagnostic accuracy of computed tomography CT vs. magnetic resonance imaging (MRI) reporting for liver metastases of pancreatic ductal adenocarcinoma (LM of PDAC). Intra-individual CT and MRI examinations of 112 patients with clinically proven LM of PDAC were included. Four radiologists with varying years of experience (A > 20, B > 5, C > 1 and D < 1) assessed liver segments affected by LM of PDAC, as well as associated metastases occurring in each patient. Their sensitivity and specificity in evaluating the segments were compared. Cohen's Kappa (κ) for diagnosed liver segments and Intra-class Correlation Coefficients (ICC) for the number of metastatic lesions in each patient were calculated. The radiologists’ sensitivity and specificity for the CT vs. MRI were, respectively: Reader A -94.4, 90.3% vs. 96.6, 94.8%; B - 86.7, 79.7% vs. 83.9, 82.0%; C - 78.0, 76.7% vs. 83.3, 78.9% and D - 71.8, 79.2% vs. 64.0, 69.5%. Reviewers A and B achieved greater agreement in assessing results from the MRI (κ = 0.72, p < 0.001; ICC = 0.73, p < 0.001) vs. the CT (κ = 0.58, p < 0.001; ICC = 0.61, p < 0.001), in contrast to readers C and D (MRI: κ = 0.34, p < 0.001; ICC = 0.42, p < 0.001, and CT: κ = 0.48, p < 0.001; ICC = 0.59, p < 0.001). Our results indicate that accurate diagnosis of LM of PDAC depends more on radiologic experience in MRI over CT scans.

Keywords

magnetic resonance imaging; multidetector computed tomography; liver; neoplasm metastasis; gadoxetic acid

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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