Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

The Missing Link in Early Emotional Processing

Version 1 : Received: 20 May 2020 / Approved: 22 May 2020 / Online: 22 May 2020 (05:26:40 CEST)
Version 2 : Received: 1 May 2021 / Approved: 11 May 2021 / Online: 11 May 2021 (10:32:30 CEST)

How to cite: Carretié, L.; Yadav, R.K.; Méndez-Bértolo, C. The Missing Link in Early Emotional Processing. Preprints 2020, 2020050348 (doi: 10.20944/preprints202005.0348.v2). Carretié, L.; Yadav, R.K.; Méndez-Bértolo, C. The Missing Link in Early Emotional Processing. Preprints 2020, 2020050348 (doi: 10.20944/preprints202005.0348.v2).


Current proposals on the temporal sequence in the processing of emotional visual stimuli are partially incompatible with growing empirical data. In the majority of them, the initial evaluation structures (IES) postulated to be in charge of the earliest detection of emotional stimuli (i.e., salient for the individual), are high order structures (i.e., those receiving visual inputs after several synapses). Thus, their latency of response cannot account for the first visual cortex response to emotional stimuli (peaking 80 ms in humans). Additionally, these proposed structures lack the necessary infrastructure to locally analyze the visual features of the stimulus (shape, color, motion, etc.) that define a stimulus as emotional. In particular, the amygdala is defended as the cornerstone IES also in humans, and cortical areas such as the ventral prefrontal cortex or the insula have been proposed as well to intervene in this initial evaluation process. The present review describes several first-order brain structures (i.e., receiving visual inputs after one synapsis), and second order structures (two synapses) that may complement the former, that accomplish with both prerequisites: presenting response latencies compatible with the observed activity at the visual cortex and possessing the necessary architecture to rudimentarily analyze in situ relevant features of the visual stimulation. The visual thalamus, and particularly the lateral geniculate nucleus (LGN), a first-order thalamic nucleus that actively processes visual information, is a good candidate to be the core IES, with the complementary action of the thalamic reticular nucleus (TRN). This LGN-TRN tandem could be supported, also in an ascending, initial evaluation phase, by the pulvinar, a second order thalamic structure, and first-order extra-thalamic nuclei (superior colliculus and certain nuclei of pretectum and the accessory optic system). In sum, the visual thalamus, scarcely studied in relation to emotional processing, is a serious candidate to be the missing link in early emotional evaluation and, in any case, is worth exploring in future research.

Subject Areas

emotion; visual thalamus; initial evaluation; lateral geniculate nucleus; thalamic reticular nucleus; pulvinar; superior colliculus

Comments (2)

Comment 1
Received: 11 May 2021
Commenter: Luis Carretié
Commenter's Conflict of Interests: Author
Comment: Clarification of some passages so they are easier to follow by non-speciallists, correction of grammar/styel/typos, inclusion of new studies in Table 2 (and references), and other minor issues.
+ Respond to this comment
Comment 2
Received: 1 June 2021
Commenter: Luis Carretié
The commenter has declared there is no conflict of interests.
Comment: Currently in press in Emotion Review
+ Respond to this comment

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 2
Metrics 0

Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.