Working Paper Article Version 1 This version is not peer-reviewed

COVID-19 Perfect Storm (Part II): Role of Vitamins as Therapy or Preventive Strategy in Aged People

Version 1 : Received: 17 May 2020 / Approved: 18 May 2020 / Online: 18 May 2020 (12:51:05 CEST)

How to cite: Fiorino, S.; Gallo, C.; Zippi, M.; Sabbatani, S.; Manfredi, R.; Moretti, R.; Fogacci, E.; Maggioli, C.; Travasoni Loffredo, F.; Giampieri, E.; Corazza, I.; Dickmans, C.; Denitto, C.; Cammarosano, M.; Battilana, M.; Orlandi, P.E.; Del Forno, F.; Miceli, F.; Visani, M.; Acquaviva, G.; Leandri, P.; Jovine, E.; Iovine, R.; de Biase, D. COVID-19 Perfect Storm (Part II): Role of Vitamins as Therapy or Preventive Strategy in Aged People. Preprints 2020, 2020050304 Fiorino, S.; Gallo, C.; Zippi, M.; Sabbatani, S.; Manfredi, R.; Moretti, R.; Fogacci, E.; Maggioli, C.; Travasoni Loffredo, F.; Giampieri, E.; Corazza, I.; Dickmans, C.; Denitto, C.; Cammarosano, M.; Battilana, M.; Orlandi, P.E.; Del Forno, F.; Miceli, F.; Visani, M.; Acquaviva, G.; Leandri, P.; Jovine, E.; Iovine, R.; de Biase, D. COVID-19 Perfect Storm (Part II): Role of Vitamins as Therapy or Preventive Strategy in Aged People. Preprints 2020, 2020050304

Abstract

Objectives: In December 2019 a novel human-infecting coronavirus, SARS-CoV-2, has emerged. The WHO has stated the epidemic as a “public health emergency of international concern”. A dramatic situation has emerged with thousands of deaths, occurring mainly in the aged and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly individuals and these subjects often present a severe deficiency in nutrients as fatsoluble and hydrosoluble vitamins. Design: In this second part of the review about Cov2 in aged people, we searched for studies describing the possible efficacy of vitamins A, D, E and C in improving the immune system function and their possible activities against viruses. Results: Vitamins may shift the proinflammatory Th17 mediated immune-response arising in the autoimmune diseases towards a T-cell regulatory phenotype. These diseases may serve as a paradigm for the study of CRS emerging in the course of SARS CoV-2 infection. Conclusion: This review discusses about the possible activity of Vitamin A, D, E and C in restoring normal antiviral Immune System function or the potential therapeutic role of these micronutrients as a part of a multi-treatment strategy against SARS-CoV-2 infection.

Subject Areas

SARS; CoV-2; COVID-19; vitamins; therapeutic strategy

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