Preprint Article Version 1 This version is not peer-reviewed

Prevalence, Pattern and Outcome of Pediatric Lassa Fever Disease (LFD) in a Tertiary Hospital, Southeast Nigeria

Version 1 : Received: 15 May 2020 / Approved: 16 May 2020 / Online: 16 May 2020 (16:41:27 CEST)

How to cite: Orji, M.; Onyire, N.; Unigwe, U.; Ajayi, N.; Nwidi, D.; Odey, E.; Agboeze, J.; Ojide, C.; Ujunwa, F.; Onwe, E.; Onoh, R.; Madume, P. Prevalence, Pattern and Outcome of Pediatric Lassa Fever Disease (LFD) in a Tertiary Hospital, Southeast Nigeria. Preprints 2020, 2020050269 (doi: 10.20944/preprints202005.0269.v1). Orji, M.; Onyire, N.; Unigwe, U.; Ajayi, N.; Nwidi, D.; Odey, E.; Agboeze, J.; Ojide, C.; Ujunwa, F.; Onwe, E.; Onoh, R.; Madume, P. Prevalence, Pattern and Outcome of Pediatric Lassa Fever Disease (LFD) in a Tertiary Hospital, Southeast Nigeria. Preprints 2020, 2020050269 (doi: 10.20944/preprints202005.0269.v1).

Abstract

The prevalence and case fatality rates of Pediatric Lassa fever disease (LFD) are not well documented. This study was aimed at determining the prevalence, pattern and outcome of Pediatric LFD. It was a prospective observational study. A total of 183 subjects that met the criteria for LFD suspects were recruited consecutively and subjected to Lassa virus PCR test. Structured questionnaire was used to collect information. Of the 183 children recruited, 24 tested positive to Lassa virus PCR, giving a positivity rate of 13.1%. Mean duration of illness at presentation was 8.54 ± 3.83 days. Fever, abdominal pain and vomiting were the three highest presenting complaints. Seven out of 24 children died giving a case fatality rate (CFR) of 29.2%. Subjects with bleeding, poor urine output, convulsions and unconsciousness were more likely to die of LFD. Positivity and CFR of LFD are high. Improved case finding and prompt treatment is advocated.

Supplementary and Associated Material

https://www.who.int: Infectious diseases-WHO

Subject Areas

case fatality; Lassa virus; pattern; positivity rate; outcome; ribavirin

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