Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Prevalence, Pattern and Outcome of Pediatric Lassa Fever Disease (LFD) in a Tertiary Hospital, Southeast Nigeria

Maria-Lauretta Orji
* ,
Nnamdi Onyire
,
Uche Unigwe
,
Nnennaya Ajayi
,
Demian Nwidi
,
Elizabeth Odey
,
Joseph Agboeze
,
Chiedozie Ojide
,
Fortune Ujunwa
,
Emeka Onwe
,
Robinson Onoh
,
Precious Madume
Version 1 : Received: 15 May 2020 / Approved: 16 May 2020 / Online: 16 May 2020 (16:41:27 CEST)

How to cite: Orji, M.; Onyire, N.; Unigwe, U.; Ajayi, N.; Nwidi, D.; Odey, E.; Agboeze, J.; Ojide, C.; Ujunwa, F.; Onwe, E.; Onoh, R.; Madume, P. Prevalence, Pattern and Outcome of Pediatric Lassa Fever Disease (LFD) in a Tertiary Hospital, Southeast Nigeria. Preprints 2020, 2020050269. https://doi.org/10.20944/preprints202005.0269.v1 Orji, M.; Onyire, N.; Unigwe, U.; Ajayi, N.; Nwidi, D.; Odey, E.; Agboeze, J.; Ojide, C.; Ujunwa, F.; Onwe, E.; Onoh, R.; Madume, P. Prevalence, Pattern and Outcome of Pediatric Lassa Fever Disease (LFD) in a Tertiary Hospital, Southeast Nigeria. Preprints 2020, 2020050269. https://doi.org/10.20944/preprints202005.0269.v1

Abstract

The prevalence and case fatality rates of Pediatric Lassa fever disease (LFD) are not well documented. This study was aimed at determining the prevalence, pattern and outcome of Pediatric LFD. It was a prospective observational study. A total of 183 subjects that met the criteria for LFD suspects were recruited consecutively and subjected to Lassa virus PCR test. Structured questionnaire was used to collect information. Of the 183 children recruited, 24 tested positive to Lassa virus PCR, giving a positivity rate of 13.1%. Mean duration of illness at presentation was 8.54 ± 3.83 days. Fever, abdominal pain and vomiting were the three highest presenting complaints. Seven out of 24 children died giving a case fatality rate (CFR) of 29.2%. Subjects with bleeding, poor urine output, convulsions and unconsciousness were more likely to die of LFD. Positivity and CFR of LFD are high. Improved case finding and prompt treatment is advocated.

Supplementary and Associated Material

https://www.who.int: Infectious diseases-WHO

Keywords

case fatality; Lassa virus; pattern; positivity rate; outcome; ribavirin

Subject

Medicine and Pharmacology, Tropical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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