Preprint Article Version 1 This version is not peer-reviewed

Post Operative Acute Kidney Injury in Gastro Intestinal and Hepatobiliary Surgery in a Tertiary Centre in Western India – A Retrospective Analysis

Version 1 : Received: 13 May 2020 / Approved: 14 May 2020 / Online: 14 May 2020 (12:03:15 CEST)

How to cite: Vasavada, B.; patel, H. Post Operative Acute Kidney Injury in Gastro Intestinal and Hepatobiliary Surgery in a Tertiary Centre in Western India – A Retrospective Analysis. Preprints 2020, 2020050239 (doi: 10.20944/preprints202005.0239.v1). Vasavada, B.; patel, H. Post Operative Acute Kidney Injury in Gastro Intestinal and Hepatobiliary Surgery in a Tertiary Centre in Western India – A Retrospective Analysis. Preprints 2020, 2020050239 (doi: 10.20944/preprints202005.0239.v1).

Abstract

AIM: Aim of our study was to evaluate incidence and causative factors for acute kidney injury in gastrointestinal and hepatobiliary surgeries. Material and methods: All the gastrointestinal surgeries performed between April 2018 to March 2020, in our institution have been analysed for acute kidney injury. Acute kidney injury defined according to acute kidney injury network classification. Categorical variables were evaluated by chi square test and continuous variables by Mann Whitney U test. Statistical analysis was done using SPSS version 23. P< 0.05 was considered significant Results: We performed 331 gastrointestinal and hepatobiliary surgery from April 2018 to March 2020. After exclusion 317 patients were included in study population.14 patients (4.4%) were defined as having acute kidney injury according to acute kidney injury network classifications. On univariate analysis acute kidney injury was associated with open surgery (p= 0.002, Intra operative hypotension (p=0.006), CDC grade of surgery (p<0.001), increased used to blood products (p=0.004), higher ASA grade (p<0.0001), increased operative time(p<0.0001). On multivariate logistic regression analysis higher ASA grade (p=0.001) and increased operative time (0.015) independently predicted acute kidney injury. Acute kidney injury was also significantly associated with 90 days mortality. ( p= <0.0001) Conclusion:Post-operative acute kidney injury was associated with significant mortality in gastrointestinal and hepatobiliary surgery. Open surgery, higher CDC grade surgery, more blood products, higher ASA grades, increase operative time predicted acute kidney injury in post operative periods. Higher ASA grades and increased operative time predicted acute kidney injury.

Subject Areas

Acute Kidney Injury; Gastrointestinal surgery; HPB surgery; perioperative care; critical care

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