Working Paper Technical Note Version 1 This version is not peer-reviewed

Application of Flow-Virometry for Large-Scale Screening of COVID 19 Cases

Version 1 : Received: 11 May 2020 / Approved: 12 May 2020 / Online: 12 May 2020 (07:45:53 CEST)

How to cite: Soni, N.; Pai, P.; Kumar G., R.K.; Prasad, V.; Dasgupta, S.; Bhadra, B. Application of Flow-Virometry for Large-Scale Screening of COVID 19 Cases. Preprints 2020, 2020050206 Soni, N.; Pai, P.; Kumar G., R.K.; Prasad, V.; Dasgupta, S.; Bhadra, B. Application of Flow-Virometry for Large-Scale Screening of COVID 19 Cases. Preprints 2020, 2020050206

Abstract

The coronavirus disease caused by SARS-CoV-2 (known as COVID 19) is highly contagious and has spread rapidly over 200 countries over last three months. WHO suggested urgent escalation in testing, isolation and contact tracing, as the "backbone" of managing the pandemic. Globally, the detection of SARS-CoV-2 in patients are done by RT-PCR and blood antibody-based testing. In addition to the existing processes, flow-cytometry could be used as a high-throughput and efficient diagnostic method for detection of COVID 19. The suspected COVID 19 samples can be analyzed using ‘Indirect flow cytometry’, with the specific primary antibody and fluorescent tagged secondary antibodies. The fluorescence signal can distinguish the infected v/s non-infected samples. In the present article, we have summarized the applications of Flow virometry to study various viruses and have proposed possible application in the detection of COVID 19.

Subject Areas

COVID-19; Severe acute respiratory syndrome (SARS); SAR-CoV-2; flow cytometry; flow virometry; viral particles; herpes simplex virus; HSV; nanoparticles

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