Preprint Review Version 1 This version is not peer-reviewed

A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models and Anti-Viral Interventions

Version 1 : Received: 11 May 2020 / Approved: 12 May 2020 / Online: 12 May 2020 (05:45:58 CEST)

How to cite: Neerukonda, S.; Katneni, U. A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models and Anti-Viral Interventions. Preprints 2020, 2020050204 (doi: 10.20944/preprints202005.0204.v1). Neerukonda, S.; Katneni, U. A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models and Anti-Viral Interventions. Preprints 2020, 2020050204 (doi: 10.20944/preprints202005.0204.v1).

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of CoV disease 2019 (COVID-19) is a highly pathogenic and transmissible CoV that is presently plaguing the global human population and economy. No proven effective anti-viral therapy or vaccine currently exist, and supportive care remains to be the cornerstone treatment. Through previous lessons learned from SARS-CoV-1 and MERS-CoV studies, scientific groups worldwide have rapidly expanded the knowledge pertaining to SARS-CoV-2 virology that included in vitro and in vivo models for testing of anti-viral therapies, and randomized clinical trials. In the present narrative, we review SARS-CoV-2 virology, clinical features, pathophysiology, and animal models with a specific focus on anti-viral and adjunctive therapies currently being tested or require testing in animal models and randomized clinical trials.

Subject Areas

SARS-CoV-2; COVID-19; animal models; anti-virals

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