Version 1
: Received: 11 May 2020 / Approved: 12 May 2020 / Online: 12 May 2020 (05:45:58 CEST)
How to cite:
Neerukonda, S.; Katneni, U. A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models and Anti-Viral Interventions. Preprints2020, 2020050204. https://doi.org/10.20944/preprints202005.0204.v1
Neerukonda, S.; Katneni, U. A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models and Anti-Viral Interventions. Preprints 2020, 2020050204. https://doi.org/10.20944/preprints202005.0204.v1
Neerukonda, S.; Katneni, U. A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models and Anti-Viral Interventions. Preprints2020, 2020050204. https://doi.org/10.20944/preprints202005.0204.v1
APA Style
Neerukonda, S., & Katneni, U. (2020). A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models and Anti-Viral Interventions. Preprints. https://doi.org/10.20944/preprints202005.0204.v1
Chicago/Turabian Style
Neerukonda, S. and Upendra Katneni. 2020 "A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models and Anti-Viral Interventions" Preprints. https://doi.org/10.20944/preprints202005.0204.v1
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of CoV disease 2019 (COVID-19) is a highly pathogenic and transmissible CoV that is presently plaguing the global human population and economy. No proven effective anti-viral therapy or vaccine currently exist, and supportive care remains to be the cornerstone treatment. Through previous lessons learned from SARS-CoV-1 and MERS-CoV studies, scientific groups worldwide have rapidly expanded the knowledge pertaining to SARS-CoV-2 virology that included in vitro and in vivo models for testing of anti-viral therapies, and randomized clinical trials. In the present narrative, we review SARS-CoV-2 virology, clinical features, pathophysiology, and animal models with a specific focus on anti-viral and adjunctive therapies currently being tested or require testing in animal models and randomized clinical trials.
Keywords
SARS-CoV-2; COVID-19; animal models; anti-virals
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
