Working Paper Article Version 2 This version is not peer-reviewed

Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 during the early phase of the pandemic in Asia

Version 1 : Received: 5 May 2020 / Approved: 6 May 2020 / Online: 6 May 2020 (15:20:27 CEST)
Version 2 : Received: 13 January 2021 / Approved: 15 January 2021 / Online: 15 January 2021 (13:14:15 CET)

How to cite: Moradi, J.; Moghoofei, M.; Doroudian, M.; Abiri, R. Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 during the early phase of the pandemic in Asia. Preprints 2020, 2020050100 Moradi, J.; Moghoofei, M.; Doroudian, M.; Abiri, R. Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 during the early phase of the pandemic in Asia. Preprints 2020, 2020050100

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as the current coronavirus pandemic is an infectious disease that initially confirmed in China in late December 2019. In this study, we analyzed 131 complete sequences of SARS-CoV-2 from Asia. Our results show that there are fifteen major mutations in Asia which most of them are co-evolved. There were five groups based on co-mutations which three of them resulted in clade G including (241C>T, 3037C>T, 14408C>T, and 23403A>G), (28881G>A, 28882G>A, 28883G>C and 23403A>G) and (25563G>T and 23403A>G). Co-mutations in (8782C>T and 28144T>C) and (1397G>A, 28688T>C, 29742G>T and 11083G>T) were clustered in clade S and a new clade outside of GISAID classification, respectively. Sequences with a mutation in 26144G>T had low variability without any co-mutation which formed clade V. In this study, we showed that Most of the circulated viruses in Asia collected in five co-mutation groups which may affect the transmissibility and vaccine designing strategies.

Subject Areas

SARS-CoV-2; Phylogenetics; Asia

Comments (1)

Comment 1
Received: 15 January 2021
Commenter: Jale Moradi
Commenter's Conflict of Interests: Author
Comment: We have added extra analysis details and discussed the results more in comparison to the previous submission. Also, we added some details to the end of the title demonstrating the time of the analysis.

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