Preprint Hypothesis Version 1 This version is not peer-reviewed

The Forrest Gump Approach to Prevent Severe COVID-19 – Reverse the Predisposing Pro-Inflammatory State with Exercise

Version 1 : Received: 1 May 2020 / Approved: 3 May 2020 / Online: 3 May 2020 (08:45:12 CEST)

How to cite: Kenyon, C. The Forrest Gump Approach to Prevent Severe COVID-19 – Reverse the Predisposing Pro-Inflammatory State with Exercise. Preprints 2020, 2020050039 (doi: 10.20944/preprints202005.0039.v1). Kenyon, C. The Forrest Gump Approach to Prevent Severe COVID-19 – Reverse the Predisposing Pro-Inflammatory State with Exercise. Preprints 2020, 2020050039 (doi: 10.20944/preprints202005.0039.v1).

Abstract

We hypothesize that the reason severe COVID-19 is closely linked to a limited number of conditions such as obesity, hypertension, older age and diabetes is that these conditions are characterized by a pro-inflammatory state in general and an angiotensin converting enzyme-1-bias in particular. We review recent evidence that this pro-inflammatory state can be reversed via regular exercise and a healthy diet. Studies are suggested that could test this hypothesis.

Subject Areas

Exercise; Angiotensin-converting enzyme; SARS-CoV-2; COVID-19; Ecology

Comments (2)

Comment 1
Received: 8 May 2020
Commenter: Martin Nelwan (Click to see Publons profile: )
The commenter has declared there is no conflict of interests.
Comment: In this manuscript, the author shows that severe COVID-19 has a relationship with such as diabetes, hypertension, obesity, and old age. Old age tend to fatter and hypertension. Therefore, old age could be susceptible to severe COVID-19. Severe COVID-19 patients are only a small portion of the disease. Old age and some chronic diseases have association with a pro-inflammation state and an imbalance in ACE1/ACE2. Overweight individuals with a high hypertension have overactive ACE1 and an underactive ACE2. It generates to pro-inflammation state. The authors did not explain why diabetes has association with severe COVID-19. It should be described as well. To reduce risk of severe COVID-19, the author hypothesized the use of exercise and healthy diet in life could reduce the risk of getting severe COVID-19. This is a potential manuscript. However, the author did not describe comprehensive information regarding exercise. For example, how many times a week a person should exercise. In addition, healthy diet was not described clearly. Tables for exercise and healthy diet should be added into this manuscript. Healthy diet from WHO is sufficient and could be added. Drugs in Clinical Trials should also be briefly described in the manuscript. This manuscript needs revisions as indicated above.
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Response 1 to Comment 1
Received: 10 May 2020
Commenter: Martin Nelwan (Click to see Publons profile: )
The commenter has declared there is no conflict of interests.
Comment: This response is only to make sure that Publons verifies the above comment.

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