Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

COVID-19: Probing the Possibility of Transmission in Animal Kingdom

Version 1 : Received: 1 May 2020 / Approved: 2 May 2020 / Online: 2 May 2020 (12:11:38 CEST)

How to cite: Kazi, T.A.; Mitra, S.; Mukhopadhyay, B.C.; Bhattacharya, R.; Mandal, S.; Biswas, S.R. COVID-19: Probing the Possibility of Transmission in Animal Kingdom. Preprints 2020, 2020050006 (doi: 10.20944/preprints202005.0006.v1). Kazi, T.A.; Mitra, S.; Mukhopadhyay, B.C.; Bhattacharya, R.; Mandal, S.; Biswas, S.R. COVID-19: Probing the Possibility of Transmission in Animal Kingdom. Preprints 2020, 2020050006 (doi: 10.20944/preprints202005.0006.v1).

Abstract

The recent 2019-nCoV outbreak, spreading infection around the globe is jeopardizing the public health and global economy. The virus was reported to have emerged from an animal market in Wuhan, China at the end of 2019 and presumed to have originated from bats and eventually transmitted in humans. The entry of the virus into human cells is triggered by a series of molecular events initiated with the binding of a receptor-binding domain of viral spike protein to human Ace2 cell surface receptor. Based on the comparative sequence analysis of the well-known binding hotspots of human Ace2, cross-interacting potential of 2019-nCoV was predicted, which suggests Ace2 of wild animals like tiger, bear, orangutan, etc.; aquatic mammals like whale and dolphins; and domestic animals like cat, horse, goat, sheep, dog etc. as potential target. However, the recognition of Ace2 of bats, rats and mice by the 2019-nCoV spike protein remains under question. The study indicates that 2019-nCoV might have broad host range and may thus intensify the gravity of 2019-nCoV outbreak

Subject Areas

2019-nCoV; intermediate host; ACE2 receptor; COVID-19

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