Preprint Review Version 1 This version is not peer-reviewed

The Epidemiology, Evolution, Transmission and Therapeutics of COVID-19 Outbreak: An Update on the Status

Version 1 : Received: 27 April 2020 / Approved: 30 April 2020 / Online: 30 April 2020 (10:39:54 CEST)

How to cite: Singh Labana, K.; Mittal, A.K.; Gujral, A. The Epidemiology, Evolution, Transmission and Therapeutics of COVID-19 Outbreak: An Update on the Status. Preprints 2020, 2020040525 (doi: 10.20944/preprints202004.0525.v1). Singh Labana, K.; Mittal, A.K.; Gujral, A. The Epidemiology, Evolution, Transmission and Therapeutics of COVID-19 Outbreak: An Update on the Status. Preprints 2020, 2020040525 (doi: 10.20944/preprints202004.0525.v1).

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an etiologic agent of the respiratory disease in humans that is known as coronavirus disease 2019 (COVID19). The first outbreak of the disease was initially documented in Wuhan, Hubei Province, China in late December 2019 where people had experienced SARS pneumonia-like symptoms with unknown etiology. Since then it has been observed that COVID-19 positive patients have been showing mild to severe upper respiratory illness symptoms. The type of virus is known to make its transfer from animals to humans and for the concerned virus; researchers have claimed its origin from bat coronavirus at whole-genome level with a 96 % sequence identity. The COVID-19 virus is very contagious and communicable in nature and has been spread throughout the globe since its first outbreak in China. On March 9, 2020, WHO declared it as a Pandemic, and within a month it was already reported to have shown its presence in 213 countries and territories or areas. As of April 29, 2020, this novel virus infected 3,218,183 people and caused 228,029 mortalities worldwide with a variable mortality rate from 3-13 % across the planet and also varied by age and gender. Diagnosis of the disease is a key component in understanding and controlling the spread of the virus and several techniques have been devised including RT-PCR, ELISA, and sequencing-based approaches. To cure COVID-19 patients as of now we do not have proven to be a safe and effective treatment. Therapeutic options currently under investigation in various parts of the world. However, there are various effective therapeutic targets to repurpose the present antiviral therapy for developing potential interventions against SARS-CoV-2. Boosting the immune system can also help to prevent and spread of COVID-19 using various medication and exercises. In this review, our goal to summarize and discussed the present scientific advancements to fight against this novel pandemic.

Subject Areas

COVID-19; evolution of SARS-CoV-2; replication; emerging disease 2019 and diagnostic tools

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