Hoque, M.N.; Chaudhury, A.; Akanda, M.A.M.; Hossain, M.A.; Islam, M.T. Genomic Diversity and Evolution, Diagnosis, Prevention, and Therapeutics of the Pandemic COVID-19 Disease. Preprints2020, 2020040359. https://doi.org/10.20944/preprints202004.0359.v1
APA Style
Hoque, M.N., Chaudhury, A., Akanda, M.A.M., Hossain, M.A., & Islam, M.T. (2020). Genomic Diversity and Evolution, Diagnosis, Prevention, and Therapeutics of the Pandemic COVID-19 Disease. Preprints. https://doi.org/10.20944/preprints202004.0359.v1
Chicago/Turabian Style
Hoque, M.N., M. Anwar Hossain and Md Tofazzal Islam. 2020 "Genomic Diversity and Evolution, Diagnosis, Prevention, and Therapeutics of the Pandemic COVID-19 Disease" Preprints. https://doi.org/10.20944/preprints202004.0359.v1
Abstract
A novel coronavirus COVID-19 was first emerged in Wuhan city of Hubei Province in China in December 2019. The COVID-19, since then spreads to 213 countries and territories, and has become a pandemic. Genomic analyses have indicated that the virus, popularly named as corona, originated through a natural process and is probably not a purposefully manipulated laboratory construct. However, currently available data are not sufficient to precisely conclude the origin of this fearsome virus. Genome-wide annotation of thousands of genomes revealed that more than 1,407 nucleotide mutations and 722 amino acids replacements occurred at different positions of the SARS-CoV-2. The spike (S) glycoprotein of SARS-CoV-2 possesses a functional polybasic (furin) cleavage site at the S1-S2 boundary through the insertion of 12 nucleotides. It leads to the predicted acquisition of 3-O-linked glycan around the cleavage site. Although real-time RT-PCR methods targeting specific gene(s) have widely been used to diagnose the COVID-19 patients, however, recently developed more convenient, rapid, and specific diagnostic tools targeting IgM/IgG or newly developed plug and play methods should be available for resource-poor developing countries. Some drugs, vaccines and therapies have shown great promise in early trials, however, these candidates of preventive or therapeutic agents have to pass a long path of trials before being released for the practical application against COVID-19. This review updates current knowledge on origin, genomic evolution, development of the diagnostic tools and the preventive or therapeutic remedies of the COVID-19, and discusses on scopes for further research and effective management and surveillance of COVID-19.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
20 April 2020
Commenter:
Mahfuz Rahman
The commenter has declared there is no conflict of interests.
Comment:
Good review article.As available reports predict possible adaptation at the nucleotide, aa, and structural heterogeneity in the
viral proteins, especially the spike (S) protein and intra-host viral evolution during infection might be related to its virulence, it may be worth to get the sequencing done of the prevalent COVID-19 virus in the Bangladesh to have some understanding what you are dealing with and how that may influence overall strategy for managing it.
The commenter has declared there is no conflict of interests.
Comment:
Dear Dr. Rahman,
Many thanks for the encouraging and valuable comment. Indeed, we need to sequence the isolates of SARS-CoV-2 from the patients of Bangladesh. Some of our researchers are planning to do it to understand the genetic identity of the Coronavirus in Bangladesh environments.
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Commenter: Mahfuz Rahman
The commenter has declared there is no conflict of interests.
viral proteins, especially the spike (S) protein and intra-host viral evolution during infection might be related to its virulence, it may be worth to get the sequencing done of the prevalent COVID-19 virus in the Bangladesh to have some understanding what you are dealing with and how that may influence overall strategy for managing it.
Commenter:
The commenter has declared there is no conflict of interests.
Many thanks for the encouraging and valuable comment. Indeed, we need to sequence the isolates of SARS-CoV-2 from the patients of Bangladesh. Some of our researchers are planning to do it to understand the genetic identity of the Coronavirus in Bangladesh environments.