Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Genomic Diversity and Evolution, Diagnosis, Prevention, and Therapeutics of the Pandemic COVID-19 Disease

Version 1 : Received: 19 April 2020 / Approved: 20 April 2020 / Online: 20 April 2020 (02:33:15 CEST)

How to cite: Hoque, M.N.; Chaudhury, A.; Akanda, M.A.M.; Hossain, M.A.; Islam, M.T. Genomic Diversity and Evolution, Diagnosis, Prevention, and Therapeutics of the Pandemic COVID-19 Disease. Preprints 2020, 2020040359 (doi: 10.20944/preprints202004.0359.v1). Hoque, M.N.; Chaudhury, A.; Akanda, M.A.M.; Hossain, M.A.; Islam, M.T. Genomic Diversity and Evolution, Diagnosis, Prevention, and Therapeutics of the Pandemic COVID-19 Disease. Preprints 2020, 2020040359 (doi: 10.20944/preprints202004.0359.v1).

Abstract

A novel coronavirus COVID-19 was first emerged in Wuhan city of Hubei Province in China in December 2019. The COVID-19, since then spreads to 213 countries and territories, and has become a pandemic. Genomic analyses have indicated that the virus, popularly named as corona, originated through a natural process and is probably not a purposefully manipulated laboratory construct. However, currently available data are not sufficient to precisely conclude the origin of this fearsome virus. Genome-wide annotation of thousands of genomes revealed that more than 1,407 nucleotide mutations and 722 amino acids replacements occurred at different positions of the SARS-CoV-2. The spike (S) glycoprotein of SARS-CoV-2 possesses a functional polybasic (furin) cleavage site at the S1-S2 boundary through the insertion of 12 nucleotides. It leads to the predicted acquisition of 3-O-linked glycan around the cleavage site. Although real-time RT-PCR methods targeting specific gene(s) have widely been used to diagnose the COVID-19 patients, however, recently developed more convenient, rapid, and specific diagnostic tools targeting IgM/IgG or newly developed plug and play methods should be available for resource-poor developing countries. Some drugs, vaccines and therapies have shown great promise in early trials, however, these candidates of preventive or therapeutic agents have to pass a long path of trials before being released for the practical application against COVID-19. This review updates current knowledge on origin, genomic evolution, development of the diagnostic tools and the preventive or therapeutic remedies of the COVID-19, and discusses on scopes for further research and effective management and surveillance of COVID-19.

Subject Areas

SARS-CoV-2; genetic diversity; genome evolution; diagnostics; therapeutics; vaccines

Comments (2)

Comment 1
Received: 20 April 2020
Commenter: Mahfuz Rahman
The commenter has declared there is no conflict of interests.
Comment: Good review article.As available reports predict possible adaptation at the nucleotide, aa, and structural heterogeneity in the viral proteins, especially the spike (S) protein and intra-host viral evolution during infection might be related to its virulence, it may be worth to get the sequencing done of the prevalent COVID-19 virus in the Bangladesh to have some understanding what you are dealing with and how that may influence overall strategy for managing it.
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Response 1 to Comment 1
Received: 21 April 2020
Commenter: Tofazzal Islam
The commenter has declared there is no conflict of interests.
Comment: Dear Dr. Rahman, Many thanks for the encouraging and valuable comment. Indeed, we need to sequence the isolates of SARS-CoV-2 from the patients of Bangladesh. Some of our researchers are planning to do it to understand the genetic identity of the Coronavirus in Bangladesh environments.

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