Should We Apply Evolutionary Theories to the Evolution of SARS-CoV-2?

Huizhi Feng

Working Paper Concept Paper Version 1 This version is not peer-reviewed

Version 1 : Received: 18 April 2020 / Approved: 19 April 2020 / Online: 19 April 2020 (13:58:58 CEST)

The outbreak of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has caused severe damage to the world. With the support of classic evolutionary theories and population genetics principles, many studies on the origin of SARS-CoV-2 have revealed encouraging results but meanwhile are still under debate. We are concerned with the validity of applying classic evolutionary theories and formula to the evolution of RNA viruses. We have raised several factors like the RNA replication feature and the RNA modification systems of the hosts, which might jeopardize the validity of the application of classic methods to analyze the SARS-CoV-2 data.

SARS-CoV-2; evolution and origin; RNA virus; application; concerns

Biology and Life Sciences, Virology

Comment 1

Received: 20 April 2020
Commenter: Can Xie
The commenter has declared there is no conflict of interests.

Comment: The deamination would skew the mutation landscape. You mean the SNPs are certainly overestimated. But what to extent are they overestimated? How many folds?

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Response 1 to Comment 1

Received: 21 April 2020
Commenter:

Huizhi

The commenter has declared there is no conflict of interests.

Comment: The last paragraph of the main text (just above the Conclusion section) may indirectly answer your question. The deamination on HIV is discussed. SARS-CoV-2 may have similar mutability.

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Should We Apply Evolutionary Theories to the Evolution of SARS-CoV-2?

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