Version 1
: Received: 18 April 2020 / Approved: 19 April 2020 / Online: 19 April 2020 (08:36:55 CEST)
How to cite:
Kashif, M.; Aamir, M.; Minhas, S.; Tahir, R.; Jahan, S.; Afzal, N. Myths and Facts: Chloroquine May Be A Potential Supportive/Therapeutic Drug in COVID-19 Treatment. Preprints2020, 2020040341. https://doi.org/10.20944/preprints202004.0341.v1
Kashif, M.; Aamir, M.; Minhas, S.; Tahir, R.; Jahan, S.; Afzal, N. Myths and Facts: Chloroquine May Be A Potential Supportive/Therapeutic Drug in COVID-19 Treatment. Preprints 2020, 2020040341. https://doi.org/10.20944/preprints202004.0341.v1
Kashif, M.; Aamir, M.; Minhas, S.; Tahir, R.; Jahan, S.; Afzal, N. Myths and Facts: Chloroquine May Be A Potential Supportive/Therapeutic Drug in COVID-19 Treatment. Preprints2020, 2020040341. https://doi.org/10.20944/preprints202004.0341.v1
APA Style
Kashif, M., Aamir, M., Minhas, S., Tahir, R., Jahan, S., & Afzal, N. (2020). Myths and Facts: Chloroquine May Be A Potential Supportive/Therapeutic Drug in COVID-19 Treatment. Preprints. https://doi.org/10.20944/preprints202004.0341.v1
Chicago/Turabian Style
Kashif, M., Shah Jahan and Nadeem Afzal. 2020 "Myths and Facts: Chloroquine May Be A Potential Supportive/Therapeutic Drug in COVID-19 Treatment" Preprints. https://doi.org/10.20944/preprints202004.0341.v1
Abstract
Quinine and its less toxic derivatives have served humanity for decades as potent antimalarial drugs. Emergence of drug resistance has narrowed the usage of these drugs in malaria prevention and treatment. Fortunately, these drugs have roles in the treatment of other diseases as well including rheumatic disorders and viral infections. Quinine derivatives have proven antiviral effects, especially against human immunodeficiency virus (HIV), Zika virus (ZiKV), herpes simplex virus (HSV), Ebola virus and dengue virus (DENV). The prophylactic and therapeutic role of Chloroquine/hydroxychroquine has become a topic of interest after the recent outbreak of novel Corona virus-19 (nCoV-19). This virus is also named severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and WHO has officially named this disease as Corona virus disease 2019 (COVID-19). This lethal virus has affected almost 186 countries of the world till to date just in a period of four months of its outbreak. No approved antiviral drug is existed for the treatment of COVID-19. Therefore, this review is focused on potential prophylactic and therapeutic role of chloroquine/hydroxychlroquine for COVID-19.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
